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Cohort Profile
 Cohort profile: the Taiwan Initiative for Geriatric Epidemiological Research - a prospective cohort study on cognition
Pei-Iun Hsieh1*orcid, Te-Hsuan Huang1*orcid, Jeng-Min Chiou2,3orcid, Jen-Hau Chen4,5orcid, Yen-Ching Chen1,6orcid
Epidemiol Health 2024;46:e2024057.
DOI: https://doi.org/10.4178/epih.e2024057
Published online: June 25, 2024

1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan

2Institute of Statistics and Data Science, National Taiwan University, Taipei, Taiwan

3Institute of Statistical Science, Academia Sinica, Taipei, Taiwan

4Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan

5Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

6Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan

Correspondence: Jen-Hau Chen Department of Geriatrics and Gerontology, National Taiwan University Hospital, 1 Chang-De Street, Taipei 10048, Taiwan E-mail: jhhchen@ntu.edu.tw
Co-correspondence: Yen-Ching Chen Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, 17 Xu-Zhou Road, Taipei 100, Taiwan E-mail: karenchen@ntu.edu.tw
*Hsieh & Huang contributed equally to this work as joint first authors.
• Received: February 29, 2024   • Accepted: June 4, 2024

© 2024, Korean Society of Epidemiology

This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • The Taiwan Initiative for Geriatric Epidemiological Research (TIGER) was founded in 2011 to elucidate the interrelationships among various predictors of global and domain-specific cognitive impairment, with the aim of identifying older adults with an increased risk of dementia in the preclinical phase. TIGER, a population-based prospective cohort, recruited 605 and 629 (total of 1,234) older adults (aged 65 and above) at baseline (2011-2013 and 2019-2022) of phase I and II, respectively. Participants have undergone structured questionnaires, global and domain-specific cognitive assessments, physical exams, and biological specimen collections at baseline and biennial follow-ups to date. By 2022, TIGER I has included 4 biennial follow-ups, with the participants comprising 53.9% female and having a mean age of 73.2 years at baseline. After an 8-year follow-up, the annual attrition rate was 6.1%, reflecting a combination of 9.9% of participants who passed away and 36.2% who dropped out. TIGER has published novel and multidisciplinary research on cognitive-related outcomes in older adults, including environmental exposures (indoor and ambient air pollution), multimorbidity, sarcopenia, frailty, biomarkers (brain and retinal images, renal and inflammatory markers), and diet. TIGER’s meticulous design, multidisciplinary data, and novel findings elucidate the complex etiology of cognitive impairment and frailty, offering valuable insights into factors that can be used to predict and prevent dementia in the preclinical phase.
  • Keywords: Cognition, Cohort studies, Aged
In March 2018, Taiwan officially became an aged society, with more than 14% of the population being older adults. As the population ages, dementia, a common geriatric syndrome, has become a critical public health concern for older adults. Alzheimer’s disease (AD), the most common cause of dementia, is characterized by cognitive and behavioral impairment that hinders daily life [1] and currently lacks effective treatment. According to the World Health Organization, more than 55 million people have been diagnosed with dementia, making it the seventh leading cause of death worldwide [2]. A survey of Taiwanese older adults (2011-2013) found an age-adjusted and sex-adjusted prevalence of 8.1% for all-cause dementia and 18.8% for mild cognitive impairment (MCI) [3]. In 2019, the number of cases attributed to all-cause dementia in Taiwan reached 0.2 million based on the National Health Insurance Database operated by the Ministry of Health and Welfare [4]. Therefore, identifying and preventing cognitive impairment before clinical manifestation is crucial.
Numerous prospective cohort studies have been established to investigate factors associated with cognitive impairment or dementia, including socio-demographics, lifestyle, environmental exposure, clinical factors, and biomarkers [5]. However, these factors vary across countries, geographic locations, and ethnic groups, and some large cohorts worldwide lack repeated measures of environmental and clinical factors (e.g., retinal biomarkers and oral examinations) [6-9]. In Taiwan, some population-based cohort studies primarily recruiting older adults have been conducted, including the Taiwan Longitudinal Study on Aging (TLSA) [10], Healthy Aging Longitudinal Study in Taiwan (HALST) [11], I-Lan Longitudinal Aging Study (ILAS) [12], and Taichung Community Health Study for Elders (TCHS-E) [13]. However, limited studies have explored multidisciplinary factors related to cognitive impairment in the preclinical phase of dementia. Additionally, only one Taiwanese cohort study, including middle-aged and older adults, collected domain-specific cognition data [12], and most studies lack regular follow-ups. Furthermore, the cognitive assessments used in some cohorts (e.g., the Mini-Mental State Exam and short Portable Mental Status Questionnaire) are not suitable for community-dwelling older adults because they have difficulty differentiating between MCI and normal cognition. Our study adopts the Montreal Cognitive Assessment (MoCA) from 2011 as it is more challenging and sensitive to small cognitive changes, enabling us to differentiate people with MCI and normal cognition [14,15]. Furthermore, although a large cross-sectional survey was conducted in Taiwan during 2011-2013 [3], providing the prevalence of MCI and all-cause dementia in Taiwanese older adults, no follow-up survey has been conducted since then. As the cognition and various health conditions of older adults tend to change over time, it is crucial to conduct a prospective cohort study with regular follow-ups that collects data on multidisciplinary factors from older adults to capture temporal changes in their health status.
Previous studies in Taiwan have mainly collected cross-sectional data on cognitive impairment [10-12,16], with limited cohort studies [16,17]. Furthermore, longitudinal data on environmental and clinical factors, as well as assessments of global and cognitive domains are especially lacking in some large cohorts worldwide. Therefore, the Taiwan Initiative for Geriatric Epidemiological Research (TIGER), a prospective cohort study, started recruiting community-dwelling older adults without dementia in 2011, with biennial follow-ups since then. TIGER has established collaborations with neurologists, geriatricians, other clinicians in various specialties, biostatisticians, epidemiologists, and experts from several other fields to collect multidisciplinary data, including lifestyle, clinical imaging (e.g., brain magnetic resonance imaging [MRI], retinal optical coherence tomography [OCT] images, and fundus photos), nutritional status (e.g., food frequency questionnaire [FFQ] and serum nutritional biomarkers), environmental exposure (e.g., air pollutants and environmental tobacco smoke), genetic factors (e.g., genetic polymorphisms in the apolipoprotein E [APOE] gene), and other biomarkers (e.g., serum metabolomic and inflammatory markers, hair cortisol level, and urine). The primary objective of TIGER is to elucidate the interrelationships among various predictors of global and domain-specific cognitive impairment, aiming to identify older adults with an increased risk of dementia in the preclinical phase. In addition to cognitive function, TIGER includes data on frailty, enabling the prediction of cognitive frailty and subsequent mortality. The longitudinal and multidisciplinary data collected through TIGER have already contributed to novel findings and will continue to do so, reinforcing the development of further research and strategies for the early prediction and prevention of dementia.
The purpose of this work is to provide the cohort profile of TIGER and summarize its critical findings. We hope to contribute to the broader understanding of the multifaceted factors related to cognitive impairment and the early identification and prevention of dementia.
Study design and population
TIGER is a prospective cohort study that aims to investigate the predictors and trajectories of cognitive impairment in community-dwelling older adults (aged ≥ 65, n=1,234). In phase I, we recruited 605 participants from the senior health check-up program of the National Taiwan University Hospital (NTUH) during the baseline period of 2011-2013. The participants have been followed biennially since then (2013-2015, 2015-2017, 2017-2019), except for the 2019-2022 wave, which was extended 1 year due to the coronavirus disease 2019 pandemic (Figure 1). In TIGER II, we recruited 629 participants at baseline (2019-2022) with the same follow-up regime.
Characteristics of the study population
The TIGER study included 605 older adults at baseline (2011-2013), with a mean age of 73.2 years (standard deviation: 5.5). Across age groups (i.e., 65-69, 70-74, 75-79, and ≥ 80), significant differences were observed in the proportion of female, years of education, annual disposable income, physical activity, gait speed, instrumental activities of daily living (IADL), hypertension, and cognitive test scores (Table 1). Table 1 includes only TIGER I information, as the key findings are mainly from this phase.
Attrition rate
In TIGER I, out of the 605 participants at baseline (2011-2013), 53.8% (n=326) remained in the cohort at the 8-year follow-up (2019-2022), 9.9% (n=60) had passed away by December 2021, and 36.2% (n=219) had dropped out due to illness, poor functional status, or being too busy to participate. There was an average annual attrition rate of 6.1% between 2011 and 2019. To address this concern, we introduced 2 key strategies: first, the inclusion of an additional 629 participants in 2019 (i.e., phase II of TIGER; Figure 1) to maintain the sample size of the cohort, and second, considering the effect of informative dropouts on the outcomes through statistical analyses [18]. These strategies are crucial for mitigating and clarifying the impact of attrition on the integrity of the study. With its well-designed cohort, continuous biennial follow-up, and expanded sample size, we anticipate that TIGER will generate further critical research findings for epidemiological studies on dementia and contribute to our understanding of aging and aged populations.
Ethics statement
This study was approved by the NTUH Research Ethics Committee (201101039RB, 201112047RIB, 201412213RINC, IRB 201712220RIN, 202012214RIN, 202112042RINA; 201312156RINC, 201712218RIN, 201812102RIN, 202012285RIN, 202112042RINA, and 202312052RINC). All participants provided written informed consent following the Declaration of Helsinki before participating in this project. The research protocol, informed consent, questionnaires, and application forms have been approved by the research ethics committee of NTUH, and all participants have provided written informed consent before joining the study.
Estimates and variables related to cognitive impairment collected in TIGER are summarized in Table 2. Longitudinal data were administered by trained interviewers from participants at baseline and each follow-up, including measures of cognitive function, questionnaires, physical measures, environmental exposure, imaging data, and biological specimens, as detailed below.
Cognitive assessment
A battery of neuropsychological tests was used to assess global and domain-specific cognition, including memory, attention, executive function, and verbal fluency at baseline and each follow-up. Global cognition was evaluated using the Taiwanese version of the Montreal Cognitive Assessment (MoCA-T), a screening tool for MCI (with a sensitivity of 0.92 and specificity of 0.78 validated in a Taiwanese population [19]). The MoCA-T score ranged from 0 to 30, with a score of ≥ 24 indicating normal cognition and < 24 indicating cognitive impairment [19]. Cognitive impairment was further grouped into MCI and suspected dementia. MCI was defined as a MoCA-T score of 22 or 23 with an intact ability to perform IADL. Suspected dementia was determined by a MoCA-T score ≤ 21 with IADL dependency [20]. Episodic memory was assessed using the logical memory-immediate and delayed theme and free recall tests in the third edition of the Wechsler Memory Scale. Attention performance was measured using the Digit Span Forward and Backward tests, with the latter also used to assess working memory. The Trail Making Test A (TMT-A) was used to evaluate attention and executive function, while the TMT-B was used to evaluate working memory and executive function. Verbal fluency tests were used to assess language function, particularly category fluency. Subjective cognitive decline was evaluated in the 8-year follow-up by asking, “Do you have cognitive difficulties compared to the previous year?” and “In the past year, have you experienced cognitive difficulties compared to others of your same age?” [21].
Imaging data
High-resolution T1-weighted volumetric MRI scans of the brain were performed using a 1.5-T scanner [22] at baseline. The MRI images were processed using the FreeSurfer suite, version 5.3. The average cerebral cortical thickness was estimated for the whole brain and some areas (frontal, parietal, temporal, occipital, limbic, and insular lobar). Additionally, the AD signature area was calculated by averaging the cortical regions including entorhinal, inferior temporal, middle temporal, temporal pole, superior parietal, inferior parietal, posterior cingulate, and precuneus [23]. OCT is used to acquire retinal biomarkers at 4-year and 10-year follow-ups of TIGER I, including retinal nerve fiber layer thickness and the ganglion cell–inner plexiform layer (GC-IPL), and fundus photography is used to collect data for estimating the vascular fractal dimension, which represents the complexity of the retinal vasculature [24,25].
Physical measures
Physical function measures are obtained through a variety of clinical examinations. Body composition, including body fat and muscle mass, is assessed using bioelectrical impedance analysis. Hand grip strength, which measures muscular strength in the hands and forearms, is evaluated using a dynamometer. The Short Physical Performance Battery, which includes 3 parts (balance test, gait speed, and repeated chair stand), is used to evaluate lower extremity function. The ankle-brachial index, which is the ratio of systolic blood pressure measured at the ankle to that measured at the brachial artery, is used to evaluate arterial perfusion in the lower extremities [26] at baseline and the 6-year follow-up. Carotid intima-media thickness was used to measure the thickness of the vessel wall at baseline using a color-coded ultrasound machine (iE33; Philips Medical Systems, Amsterdam, the Netherlands) with a 3 to 11-MHz linear-array transducer for the extra cranial arteries. Olfactory function is assessed using the Sniffin’ Sticks Identification Test to evaluate odor identification ability [27] at the 4-year and 8-year follow-ups and thereafter. Finally, oral health conditions, including periodontal status, tooth defects, and dentition, are evaluated through oral examinations conducted by dentists at baseline, 6-year follow-up, and thereafter.
Clinical measures and other covariates
TIGER collects information on several clinical measures and covariates. The medical history of each participant included more than 20 conditions and medication use. Physical activities are assessed using a short version of the International Physical Activity Questionnaire. The participants’ functional status is evaluated using the Barthel index for activities of daily living and IADL. Depressive symptoms are assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). Sleep quality and disturbances during the past month are evaluated using the Pittsburgh Sleep Quality Index (PSQI). Daytime sleepiness is evaluated using the Epworth Sleepiness Scale, which measures the likelihood of a person dozing off during the day in various situations. Finally, TIGER uses a 44-item semi-quantitative FFQ, which is a shortened version of a validated 64-item FFQ for the Taiwanese population, to assess participants’ dietary intake in the previous year [28].
Environmental exposure
Data on ambient air pollutants are collected from 29 monitoring stations located in Taipei, Keelung, and Taoyuan Cities, through the Taiwan Air Quality Monitoring Network established by the Taiwan Environmental Protective Administration (EPA) from 1994 to the present (https://www.epa.gov.tw/ENG/). Bayesian Maximum Entropy is used to estimate the spatiotemporal distribution of 6 air pollutants (particulate matter with a diameter less than 2.5 μm [PM2.5], particulate matter with a diameter less than 10 μm [PM10], sulfur dioxide [SO2], carbon monoxide [CO], nitrogen dioxide [NO2], and ozone [O3]) and the individual’s residential exposure to these pollutants [29]. Additionally, TIGER assesses indoor air quality by examining daily indoor time (in hours) and ventilation status defined by window/door openness and use of air-circulating equipment.
Biological specimens
In addition to the blood data (high- and low-density lipoprotein, and creatinine) and urinary protein from the senior health check-up program at NTUH, we additionally collect blood samples from each participant to determine the concentration of high-sensitivity C-reactive protein, homocysteine, vitamin B12, folate, triglyceride, total cholesterol, tumor necrosis factor-alpha, and cystatin C. Metabolomic profiles are determined at baseline through a nuclear magnetic resonance (NMR) spectroscopy and analyzed by the Chenomx NMR Suite software (Chenomx Inc., Edmonton, AB, Canada), based on chemical shifts (ppm) and the multiplicity of the peak [30]. The APOE e4 status was determined by genotyping 2 single nucleotide polymorphisms, rs42938 and rs7412, using TaqMan assays based on the ABI 7900HT fast real-time PCR system (Applied Biosystems Inc., Foster City, CA, USA [31]).
Other outcomes
The study also assesses frailty status based on modifications of the criteria of Fried et al. [32]. Cognitive frailty is defined based on the consensus from the International Academy of Nutrition and Aging and the International Association of Gerontology and Geriatrics (IANA-IAGG) in 2013, and extended definitions were developed in our previous work based on various cognitive domains and physical and/or psychosocial frailty [33]. The TIGER data have been linked with the national death registry up to December 2021, and the data from the senior health check-up program at NTUH have been incorporated to obtain data from health check-ups. Additionally, healthcare utilization, including the number of hospitalizations and operations, is also collected.
Cognition, frailty, handgrip strength, and mortality
In 2020, we newly proposed extended definitions of cognitive frailty, exploring the combination of frailty dimensions (i.e., physical, psychosocial, and global frailty) and impaired cognitive domains. The difference between the 2013 definition of cognitive frailty by IANA-IAGG and our cognitive-global frailty is that our global frailty further includes “psychosocial frailty,” a component not included in the 2013 definition but crucial for the well-being of older adults. We found that cognitive-global frailty had a better predictive ability for all-cause mortality in older adults than the traditional definition proposed by the IANA-IAGG in 2013 [34]. Additionally, we found that physical frailty was associated with poor global cognition, memory, and executive function, while psychosocial frailty was associated with poor global cognition and attention [33]. In 2022, our findings showed that severe sarcopenia and poor grip strength were associated with both global and domain-specific cognitive impairment in older adults [35]. A subsequent 7-year study demonstrated that, males with reduced handgrip strength and handgrip strength asymmetry were associated with a higher risk of cognitive impairment across various domains, compare with females [36].
Air pollutants and cognition
To investigate the impact of environmental exposure on cognitive function, we investigated and found that long-term exposure (1994-2017) to low-level air pollutants (below EPA standards) was associated with poor cognitive performance over a 4-year period [37]. In 2023, we newly explored the interaction between indoor air quality and low-level exposure to outdoor air pollutants, including PM2.5, PMcoarse, NO2, O3, SO2, and CO [38]. This study also proposed novel multi-pollutant models that more accurately reflect real-world situations. Furthermore, a ventilation score was newly developed to assess indoor air quality based on daily indoor time and ventilation status, taking into account window/door openness and the use of air-circulation equipment during the day and night over 4 seasons. Our findings could potentially inform amendments to air quality standards and underscore the importance of the impact of indoor air quality on cognition.
Lifestyle, diet, and cognition
Additionally, TIGER has investigated the impact of modifiable lifestyle factors on cognitive function. Our research demonstrated that 5 lifestyle factors, including high intake of vegetables and fish, regular exercise, not smoking, and light to moderate alcohol consumption, as well as 3 socioeconomic status indicators (high annual household income [> 33,333 US dollar], high occupational complexity, and high education level [> 12 years]), were significantly protective against cognitive decline [39]. Due to geographic differences in food resources and dietary habits, in 2017, we newly identified 3 dietary patterns (“vegetable,” “meat,” and “traditional”) among Chinese ethnic older adults. Our results suggested that the “vegetable” and “traditional” dietary patterns, which included fermented foods and pickled vegetables, protected against memory decline, while the “meat” dietary pattern increased the risk of verbal fluency decline [40]. In 2019, another study from TIGER indicated that a high-quality diet (assessed by the modified Alternative Healthy Eating Index based on the Dietary Guidelines for Americans and Food Patterns Equivalents database) was associated with a lower risk of global cognitive and attention decline over 2 years, and the results became more evident in participants with a high diversity of vegetable intake [41]. Furthermore, only a limited number of studies have repeatedly collected dietary data. In this elderly Asian population with longitudinal data, we were able to identify 3 distinct trajectories of dietary quality (“deteriorating,” “improving,” and “stable-high”) over 6 years [42]. Our findings showed that maintaining consistently high dietary quality was linked to better cognitive performance, emphasizing the critical role of promoting sound diet quality in older adults.
Helicobacter pylori, retinal markers, and cognition
Our research team has also studied various biomarkers (e.g., retinal images, and immunoglobulin G (IgG) levels for Helicobacter pylori exposure) and disease patterns. A cross-sectional study from TIGER showed that the highest quartile of H. pylori IgG levels was associated with poor language and attention performance compared with the lowest quartile [43]. Additionally, our study newly found a U-shape association (i.e., thinning or thickening of GC-IPL) with poor global cognition and memory performance in non-demented older adults, suggesting that it may serve as a noninvasive preclinical predictor of dementia [24]. We further investigated the association between retinal vascular complexity, estimated by fractal dimension, and cognition. Our results suggest that a reduction in retinal vascular complexity, in either the right or left eye, is associated with varying degrees of impairment in global or domain-specific cognition [25]. These findings show that retinal markers could predict the risk of dementia in the preclinical phase.
Renal function, olfactory function, and cognition
For research on kidney dysfunction and cognitive function, a cross-sectional study in TIGER showed that kidney dysfunction was associated with poor global cognition and lower frontal, partial, temporal, occipital, and insular lobar cerebral cortical thickness [22]. In 2020, a 4-year study from TIGER revealed that kidney dysfunction and cortical thinning jointly contributed to cognitive decline, especially in attention performance [23]. Another 4-year study found that odor identification deficits had an increased risk of poor global or domain-specific cognitive function in dementia-free older adults [44].
Comorbidities, sleep, and cognition
In 2023, we identified sex-specific multimorbid patterns in older Taiwanese and found that they were differentially associated with poor cognitive performance in the presence of informative dropouts [18]. These multimorbid patterns (especially the “renal-vascular” pattern in males) were different from the patterns observed in Western countries, as renal diseases are more prevalent in Taiwan. Additionally, few studies have examined the relationship between subclinical depression and cognitive impairment, particularly MCI, while taking into account factors including sleep quality and daytime sleepiness. Our study investigated the interplay between these variables and found that good sleep quality, coupled with the absence of excessive daytime sleepiness, was associated with better memory performance over time. These findings highlight the significance of sleep and its relationship with preclinical depression and cognition among older adults [45].
This study has several strengths. First, TIGER includes a comprehensive range of geriatric assessments and links the data with the national mortality registry and medical records from the senior health check-up program of NTUH. Although several epidemiological cohorts including community-dwelling older adults have been established in Taiwan [10-13], most have focused on general geriatric conditions, lacked data on domain-specific cognitive performance, and/or had irregular follow-up or cross-sectional data. Additionally, we used long-term (> 20 years) air pollutants data collected by monitoring stations of the Taiwan EPA to estimate individuals’ residential exposure to air pollutants in the study area (Taipei metropolis), which is better than regional exposure and exposure based on the area of clinic visit. Second, the biennially repeated measures of cognition and other variables, as well as blood sample collection every 4 years, provide valuable information on the temporal changes in health status, particularly cognitive performance and frailty, in older adults, in older adults. The data from TIGER allow us to fill in these gaps in the Taiwanese older population over the past decade, and make important comparisons with findings from Western countries. Third, to reduce dropout, we conducted telephone interviews for participants who were unable to attend a face-to-face interview during follow-ups. Therefore, the mean annual attrition rate in TIGER is 6.1%, which is lower than the average attrition rate of other cohorts including older adults [46]. This low attrition rate reflects the careful design and maintenance of this cohort study.
The study has some limitations. First, TIGER participants were recruited from a senior health check-up program in northern Taiwan (a metropolitan area with a higher educational level, i.e., only < 3% with years of education < 6 years), which may limit the generalizability of the findings to older populations in rural or suburban areas. However, the MCI prevalence in TIGER I (18.4%) is similar to that in a national survey during 2011-2013 [3], and the age-sex-adjusted incidence rate of suspected dementia (12.5 per 1,000 person-years) is close to that reported in a population-based study conducted with Asian Americans during 1999-2019 [47]. Participants who attended the health check-up program tended to be healthier than the general population at baseline. However, as the follow-up time increased, the participants’ health status declined and became more representative of the general population [48]. Second, the availability of repeated neuroimaging data was limited due to funding constraints and the willingness of participants to undergo re-assessment. Nonetheless, neuroimaging characteristics may change over time, and including repeated data on neuroimaging factors may be considered in future investigations to advance our understanding of the progression of cognitive impairment.
We are looking forward to more collaborations with national and international studies via data sharing. Those interested in collaboration or data sharing are welcome to contact the corresponding authors: Yen-Ching Chen (e-mail: karenchen@ntu.edu.tw) and Jen-Hau Chen (e-mail: jhhchen@ntu.edu.tw). Further information about TIGER can be acquired by visiting the website (https://homepage.ntu.edu.tw/~karenchen/projects.html) or contacting the corresponding authors via e-mails.

Conflict of interest

The authors have no conflicts of interest to declare for this study.

Funding

This study was supported by the Taiwan Ministry of Science and Technology (100-2314-B-002-103, 101-2314-B-002-126-MY3, 104-2314-B-002-038-MY3, 107-2314-B-002-186-MY3, 110-2314-B-002-068, and 111-2314-B-002-090-MY3; 103-2314-B-002-033-MY3, 107-2314-B-002-230, 108-2314-B-002-128-MY2, 110-2314-B-002-129-MY3, 202112042RINA, and 202312052RINC).

Author contributions

Conceptualization: Chen JH, Chen YC. Data curation: Chen JH, Chen YC. Formal analysis: Hsieh PI, Huang TH, Chiou JM. Funding acquisition: Chen JH, Chen YC. Methodology: Chen JH, Chen YC. Project administration: Chen JH, Chen YC. Validation: Hsieh PI, Huang TH, Chen YC. Visualization: Hsieh PI, Huang TH, Chen YC. Writing–original draft: Hsieh PI, Huang TH, Chen YC. Writing–review & editing: Hsieh PI, Huang TH, Chiou JM, Chen JH, Chen YC.

We are grateful to the participants for their willingness to join this study and to all researchers who have contributed to the design, and data collection. We appreciate the technical support provided by the Sequencing and Biochemistry Core, Department of Medical Research, National Taiwan University Hospital. We are also grateful for the access to the NMR analysis provided by Academia Sinica High-Field NMR Center (HFNMRC); HFNMRC is supported by Academia Sinica (AS-CFII-111-214).
The funding sources had no role in the study design, method, subject recruitment, data collection, analyses, and paper preparation.
Figure 1.
A conceptual timeline of Taiwan Initiative for Geriatric Epidemiological Research (TIGER; 2011 to present; n=1,234) Covariates included the questionnaire variables, and the measurements of physical, biochemical, and genetic. EPA, Environmental Protection Administration; PM, particulate matter; PM2.5, particulate matter with a diameter less than 2.5 μm; SO2, sulfur dioxide; CO, carbon monoxide; NO2, nitrogen dioxide; O3, ozone.
epih-46-e2024057f1.jpg
Table 1.
Characteristics of TIGER I study participants by age groups at baseline (2011-2013, n=605)
Variables Age (yr)
 Total (n=605)
65-69 (n=192) 70-74 (n=186) 75-79 (n=132) ≥80 (n=95)
Education (yr) 13.9±3.2* 13.6±3.8* 12.4±4.5* 12.9±4.7* 13.3±4.0
BMI (kg/m2) 24.1±3.0 23.9±2.7 23.9±3.4 23.9±2.9 24.0±3.0
Physical activity (MET-min/wk) 1,847.9±1,348.6* 1,900.6±1,924.3* 1,535.7±1,391.8* 1,415.8±1,201.1* 1,728.1±1,546.3
Gait speed (8 feet; sec) 3.1±0.7* 3.3±1.1* 3.8±1.1* 4.0±1.3* 3.4±1.1
ADL 99.5±2.1 99.3±3.2 98.7±3.1 99.5±9.7 99.3±4.6
IADL 7.9±0.6* 7.8±0.5* 7.8±0.6* 7.6±1.1* 7.8±0.7
MoCA-T score 27.3±2.2* 26.4±2.9* 25.2±3.9* 23.9±4.2* 26±3.4
LM: immediate theme recall1 0.28±0.86* 0.10±0.93* -0.19±1.04* -0.51±1.10* 0±1.0
LM: immediate free recall1 0.38±0.94* 0.06±0.91* -0.22±1.01* -0.57±0.93* 0±1.0
LM: delayed theme recall1 0.30±0.85* 0.06±0.94* -0.18±1.05* -0.47±1.10* 0±1.0
LM: delayed free recall1 0.37±0.97* 0.04±0.92* -0.21±1.01* -0.52±0.91* 0±1.0
Digit span forward1 0.44±0.68* 0.10±0.86* -0.33±1.14* -0.65±1.11* 0±1.0
Digit span backward1 0.31±0.97* 0.02±0.98* -0.24±0.95* -0.36±0.97* 0±1.0
Trail Making Test- Part A1 0.41±0.56* 0.06±0.99* -0.27±1.04* -0.58±1.24* 0±1.0
Trail Making Test- Part B1 0.42±0.84* 0.14±0.90* -0.31±0.98* -0.71±1.02* 0±1.0
Verbal fluency tests1 0.42±0.90* 0.07±0.90* -0.17±0.99* -0.73±0.94* 0±1.0
Female 129 (67.2)* 96 (51.6)* 68 (51.5)* 33 (34.7)* 326 (53.9)
APOE e4 carriers 27 (14.1) 38 (20.7) 20 (15.3) 12 (12.6) 97 (16.1)
Annual disposable income >USD 33,333 85 (47.0)* 80 (45.7)* 47 (38.5)* 35 (38.9)* 247 (43.5)
Cigarette smoking 30 (15.6) 25 (13.4) 19 (14.4) 23 (24.2) 97 (16.0)
Alcohol consumption 37 (19.3) 38 (20.4) 24 (18.2) 24 (25.3) 123 (20.3)
Depressive symptoms 18 (9.4) 12 (6.5) 16 (12.1) 7 (7.4) 53 (8.8)
Hypertension 90 (46.9)* 116 (62.4)* 100 (75.8)* 70 (73.7)* 376 (62.2)
Hyperlipidemia 101 (52.6) 95 (51.1) 67 (50.8) 45 (47.4) 308 (50.9)
Diabetes mellitus 29 (15.1) 28 (15.1) 22 (16.7) 15 (15.8) 94 (15.5)

Values are presented as mean±standard deviation or number (%).

TIGER, Taiwan Initiative for Geriatric Epidemiological Research; BMI, body mass index; MET, metabolic equivalent of task; ADL, activities of daily living; IADL, instrumental activities of daily living; MoCA-T, Taiwanese version of the Montreal Cognitive Assessment; LM, logical memory; APOE, apolipoprotein E; MCI, mild cognitive impairment; USD, US dollar.

1 To facilitate comparisons across different domain-specific cognitive tests, we standardized all cognitive test scores by Z transformation based on the mean and standard deviation at the baseline of each test; A higher standardized cognitive score in all neuropsychological measures indicated better performance.

* p<0.05.

Table 2.
Data collection at each follow-up of TIGER I (2011-2024)
Data Baseline (2011-2013) Follow-up 1 (2013-2015) Follow-up 2 (2015-2017) Follow-up 3 (2017-2019) Follow-up 4 (2019-2022) Follow-up 5 (2022-2024)
Cognitive assessment
 Global cognition: MoCA-T O O O O O O
 Memory domain: WMS-III logical memory O O O O O O
 Executive function: Trail-making test O O O O O O
 Attention domain: WMS-III Digit span test O O O O O O
 Verbal fluency O O O O O O
Questionnaire
 Socio-demography and anthropometry O - - - O O
 Medical history (disease and medication) O O O O O O
 Physical activity: IPQA O O O O O O
 Physical function: ADL, IADL O O O O O O
 Depressive symptoms: CESD O O O O O O
 Sleep assessment: PSQI, ESS - - O O O O
 Stressful life events: SRRS - - O O O O
 Dietary data: FFQ O - O O O O
 Swallowing function: Eat-10 - - - - - O
 Hearing assessment: HHIE - - - - - O
Physical measures
 Body composition: BIA O O O O O O
 Hand grip strength - - O O O O
 Lower extremity function: SPPB O O O O O O
 Ankle-brachial index O - - O - -
 Intima-media thickness O - - - - -
 Retinal imaging: fundus photography, OCT - - O - - O
 Olfactory function: SSIT - - O - O O
 Dental assessment O - - O O O
 Brain images: MRI O - - - - -
Environmental exposure
 Air pollutants exposure O O O O O O
 Indoor air quality - - - O O O
Biological specimens
 Serum markers, DNA O - O - O -
 Metabolomics NMR (plasma) O - - - - -
 Urine - - - - O -
 Hair - - O - - -
Other outcomes of interests:
 Frailty O O O O O O
 Mortality, health care utilization - O O O O O

Data collection in TIGER II (2019-present, n=629) is consistent with TIGER I from follow-up 4 and thereafter.

TIGER, Taiwan Initiative for Geriatric Epidemiological Research; MoCA-T, Taiwanese version of the Montreal Cognitive Assessment; WMS, Wechsler Memory Scale; IPAQ, International Physical Activity Questionnaire; ADL, activities of daily living; IADL, instrumental activities of daily living; CSED, Center for Epidemiological Studies-Depression; PSQI, Pittsburgh Sleep Quality Index; ESS, Epworth Sleepiness Scale; SRRS, Social Readjustment Rating Scale; FFQ, food frequency questionnaire; HHIE, Hearing Handicap Inventory for the Elderly; BIA, bioelectrical impedance analysis; SPPB, Short Physical Performance Battery; OCT, optical coherence tomography; SSIT, Sniffin’ Sticks Identification Test; MRI, magnetic resonance imaging; DNA, deoxyribonucleic acid; NMR, nuclear magnetic resonance.

Figure & Data

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      Cohort profile: the Taiwan Initiative for Geriatric Epidemiological Research - a prospective cohort study on cognition
      Image
      Figure 1. A conceptual timeline of Taiwan Initiative for Geriatric Epidemiological Research (TIGER; 2011 to present; n=1,234) Covariates included the questionnaire variables, and the measurements of physical, biochemical, and genetic. EPA, Environmental Protection Administration; PM, particulate matter; PM2.5, particulate matter with a diameter less than 2.5 μm; SO2, sulfur dioxide; CO, carbon monoxide; NO2, nitrogen dioxide; O3, ozone.

      Figure 1.

      Cohort profile: the Taiwan Initiative for Geriatric Epidemiological Research - a prospective cohort study on cognition
      Variables Age (yr)
      		 Total (n=605)
      65-69 (n=192) 70-74 (n=186) 75-79 (n=132) ≥80 (n=95)
      Education (yr) 13.9±3.2* 13.6±3.8* 12.4±4.5* 12.9±4.7* 13.3±4.0
      BMI (kg/m2) 24.1±3.0 23.9±2.7 23.9±3.4 23.9±2.9 24.0±3.0
      Physical activity (MET-min/wk) 1,847.9±1,348.6* 1,900.6±1,924.3* 1,535.7±1,391.8* 1,415.8±1,201.1* 1,728.1±1,546.3
      Gait speed (8 feet; sec) 3.1±0.7* 3.3±1.1* 3.8±1.1* 4.0±1.3* 3.4±1.1
      ADL 99.5±2.1 99.3±3.2 98.7±3.1 99.5±9.7 99.3±4.6
      IADL 7.9±0.6* 7.8±0.5* 7.8±0.6* 7.6±1.1* 7.8±0.7
      MoCA-T score 27.3±2.2* 26.4±2.9* 25.2±3.9* 23.9±4.2* 26±3.4
      LM: immediate theme recall1 0.28±0.86* 0.10±0.93* -0.19±1.04* -0.51±1.10* 0±1.0
      LM: immediate free recall1 0.38±0.94* 0.06±0.91* -0.22±1.01* -0.57±0.93* 0±1.0
      LM: delayed theme recall1 0.30±0.85* 0.06±0.94* -0.18±1.05* -0.47±1.10* 0±1.0
      LM: delayed free recall1 0.37±0.97* 0.04±0.92* -0.21±1.01* -0.52±0.91* 0±1.0
      Digit span forward1 0.44±0.68* 0.10±0.86* -0.33±1.14* -0.65±1.11* 0±1.0
      Digit span backward1 0.31±0.97* 0.02±0.98* -0.24±0.95* -0.36±0.97* 0±1.0
      Trail Making Test- Part A1 0.41±0.56* 0.06±0.99* -0.27±1.04* -0.58±1.24* 0±1.0
      Trail Making Test- Part B1 0.42±0.84* 0.14±0.90* -0.31±0.98* -0.71±1.02* 0±1.0
      Verbal fluency tests1 0.42±0.90* 0.07±0.90* -0.17±0.99* -0.73±0.94* 0±1.0
      Female 129 (67.2)* 96 (51.6)* 68 (51.5)* 33 (34.7)* 326 (53.9)
      APOE e4 carriers 27 (14.1) 38 (20.7) 20 (15.3) 12 (12.6) 97 (16.1)
      Annual disposable income >USD 33,333 85 (47.0)* 80 (45.7)* 47 (38.5)* 35 (38.9)* 247 (43.5)
      Cigarette smoking 30 (15.6) 25 (13.4) 19 (14.4) 23 (24.2) 97 (16.0)
      Alcohol consumption 37 (19.3) 38 (20.4) 24 (18.2) 24 (25.3) 123 (20.3)
      Depressive symptoms 18 (9.4) 12 (6.5) 16 (12.1) 7 (7.4) 53 (8.8)
      Hypertension 90 (46.9)* 116 (62.4)* 100 (75.8)* 70 (73.7)* 376 (62.2)
      Hyperlipidemia 101 (52.6) 95 (51.1) 67 (50.8) 45 (47.4) 308 (50.9)
      Diabetes mellitus 29 (15.1) 28 (15.1) 22 (16.7) 15 (15.8) 94 (15.5)
      Data Baseline (2011-2013) Follow-up 1 (2013-2015) Follow-up 2 (2015-2017) Follow-up 3 (2017-2019) Follow-up 4 (2019-2022) Follow-up 5 (2022-2024)
      Cognitive assessment
       Global cognition: MoCA-T O O O O O O
       Memory domain: WMS-III logical memory O O O O O O
       Executive function: Trail-making test O O O O O O
       Attention domain: WMS-III Digit span test O O O O O O
       Verbal fluency O O O O O O
      Questionnaire
       Socio-demography and anthropometry O - - - O O
       Medical history (disease and medication) O O O O O O
       Physical activity: IPQA O O O O O O
       Physical function: ADL, IADL O O O O O O
       Depressive symptoms: CESD O O O O O O
       Sleep assessment: PSQI, ESS - - O O O O
       Stressful life events: SRRS - - O O O O
       Dietary data: FFQ O - O O O O
       Swallowing function: Eat-10 - - - - - O
       Hearing assessment: HHIE - - - - - O
      Physical measures
       Body composition: BIA O O O O O O
       Hand grip strength - - O O O O
       Lower extremity function: SPPB O O O O O O
       Ankle-brachial index O - - O - -
       Intima-media thickness O - - - - -
       Retinal imaging: fundus photography, OCT - - O - - O
       Olfactory function: SSIT - - O - O O
       Dental assessment O - - O O O
       Brain images: MRI O - - - - -
      Environmental exposure
       Air pollutants exposure O O O O O O
       Indoor air quality - - - O O O
      Biological specimens
       Serum markers, DNA O - O - O -
       Metabolomics NMR (plasma) O - - - - -
       Urine - - - - O -
       Hair - - O - - -
      Other outcomes of interests:
       Frailty O O O O O O
       Mortality, health care utilization - O O O O O
      Table 1. Characteristics of TIGER I study participants by age groups at baseline (2011-2013, n=605)

      Values are presented as mean±standard deviation or number (%).

      TIGER, Taiwan Initiative for Geriatric Epidemiological Research; BMI, body mass index; MET, metabolic equivalent of task; ADL, activities of daily living; IADL, instrumental activities of daily living; MoCA-T, Taiwanese version of the Montreal Cognitive Assessment; LM, logical memory; APOE, apolipoprotein E; MCI, mild cognitive impairment; USD, US dollar.

      To facilitate comparisons across different domain-specific cognitive tests, we standardized all cognitive test scores by Z transformation based on the mean and standard deviation at the baseline of each test; A higher standardized cognitive score in all neuropsychological measures indicated better performance.

      p<0.05.

      Table 2. Data collection at each follow-up of TIGER I (2011-2024)

      Data collection in TIGER II (2019-present, n=629) is consistent with TIGER I from follow-up 4 and thereafter.

      TIGER, Taiwan Initiative for Geriatric Epidemiological Research; MoCA-T, Taiwanese version of the Montreal Cognitive Assessment; WMS, Wechsler Memory Scale; IPAQ, International Physical Activity Questionnaire; ADL, activities of daily living; IADL, instrumental activities of daily living; CSED, Center for Epidemiological Studies-Depression; PSQI, Pittsburgh Sleep Quality Index; ESS, Epworth Sleepiness Scale; SRRS, Social Readjustment Rating Scale; FFQ, food frequency questionnaire; HHIE, Hearing Handicap Inventory for the Elderly; BIA, bioelectrical impedance analysis; SPPB, Short Physical Performance Battery; OCT, optical coherence tomography; SSIT, Sniffin’ Sticks Identification Test; MRI, magnetic resonance imaging; DNA, deoxyribonucleic acid; NMR, nuclear magnetic resonance.

      Table 1.

      Table 2.

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