Epidemiology and Health

From articles published in Epidemiology and Health during the past two years (2023 ~ ).

Special Articles

The Korea National Disability Registration System: Miso Kim, Wonyoung Jung, So Young Kim, Jong Hyock Park, Dong Wook Shin; Epidemiol Health. 2023;45:e2023053. Published online May 11, 2023; DOI: https://doi.org/10.4178/epih.e2023053

19,388 View
323 Download
35 Web of Science
35 Crossref

Abstract Summary PDF Supplementary Material

Abstract

The Korea National Disability Registration System (KNDRS) was established in 1989 to provide social welfare benefits based on predefined criteria for disability registration and an objective medical assessment using a disability grading system. Disability registration requires (1) a medical examination by a qualified specialist physician and (2) a medical advisory meeting to review the degree of disability. Medical institutions and specialists for the diagnosis of disabilities are legally stipulated, and medical records for a specified period are required to support the diagnosis. The number of disability types has gradually expanded, and 15 disability types have been legally defined. As of 2021, 2.645 million people were registered as disabled, accounting for approximately 5.1% of the total population. Among the 15 disability types, disabilities of the extremities account for the largest proportion (45.1%). Previous studies have investigated the epidemiology of disabilities using data from the KNDRS, combined predominantly with data from the National Health Insurance Research Database (NHIRD). Korea has a mandatory public health insurance system that covers the entire Korean population, and the National Health Insurance Services manages all eligibility information, including disability types and severity ratings. In short, the KNDRS-NHIRD is a significant data resource for research on the epidemiology of disabilities.

Summary

Korean summary
한국에서는 장애의 유형과 장애 유형별 장애정도를 장애인 복지법에서 규정하고 있다. 우리는 한국의 장애등록제도의 역사와 장애등록절차 그리고 장애유형별 통계 현황에 대해서 다루고자 한다.

Key Message
In Korea, the types and severity levels of disabilities are legally defined by the Korea National Disability Registration System (KNDRS). We address the history of the KNDRS, disability registration procedures, and current statistics.

Citations

Citations to this article as recorded by

Longitudinal analysis of anxiety and sleep disorders in the Korean population with disabilities, from 2006 to 2017: Incidence, prevalence, and association with disability type and severity
H.-Y. Lee, K.E. Yeob, S.Y. Kim, Y.Y. Kim, J.H. Park
Journal of Affective Disorders.2025; 369: 135. CrossRef
Association between Age-Related Macular Degeneration with Visual Disability and Risk of Dementia: A Nationwide Cohort Study
Ki Young Son, Yong-Jun Choi, Bongseong Kim, Kyungdo Han, Sungsoon Hwang, Wonyoung Jung, Dong Wook Shin, Dong Hui Lim
Journal of the American Medical Directors Association.2025; 26(2): 105392. CrossRef
Intellectual disabilities and risk of cardiovascular diseases: A population-based cohort study
In Young Cho, Hye Yeon Koo, Yoo Jin Um, Yong-Moon Mark Park, Kyung Mee Kim, Chung Eun Lee, Kyungdo Han
Disability and Health Journal.2025; 18(2): 101754. CrossRef
Elevated risk of end-stage kidney disease in stroke patients: A population-based observational study
Sohyun Chun, Kyungdo Han, Bongseong Kim, Dagyeong Lee, In Young Cho, Hea Lim Choi, Jun Hee Park, Junseok Jeon, Hye Ryoun Jang, Dong Wook Shin
International Journal of Stroke.2025; 20(4): 461. CrossRef
Increased risk of type 2 diabetes after traumatic amputation: a nationwide retrospective cohort study
Jung Eun Yoo, Dagyeong Lee, Bongseong Kim, Won Hyuk Chang, Sang-Man Jin, Kyungdo Han, Dong Wook Shin
Frontiers in Endocrinology.2025;[Epub] CrossRef
Increased Risk of End-Stage Kidney Disease After Traumatic Amputation: Nationwide Cohort Study
Jung Eun Yoo, Bongseong Kim, Won Hyuk Chang, Kyungho Lee, Hye Ryoun Jang, Kyungdo Han, Dong Wook Shin
Healthcare.2025; 13(1): 80. CrossRef
Association between chemotherapy and the risk of developing breast cancer-related lymphedema: a nationwide retrospective cohort study
Sung Hoon Jeong, Seong Min Chun, Hyunji Lee, Miji Kim, Mira Choi, Ja-Ho Leigh
Supportive Care in Cancer.2025;[Epub] CrossRef
Impact of acupuncture on mortality in patients with disabilities and newly diagnosed heart failure: a nationwide cohort study
Hyungsun Jun, Dasol Park, Jae-Uk Sul, Moon Joo Cheong, Haerim Kim, Inae Youn, Jungtae Leem
Frontiers in Medicine.2025;[Epub] CrossRef
Risk of Diabetes Mellitus in Adults with Intellectual Disabilities: A Nationwide Cohort Study
Hye Yeon Koo, In Young Cho, Yoo Jin Um, Yong-Moon Mark Park, Kyung Mee Kim, Chung Eun Lee, Kyungdo Han
Endocrinology and Metabolism.2025; 40(1): 103. CrossRef
The link between disability and social participation revisited: Heterogeneity by type of social participation and by socioeconomic status
Jinho Kim, Gum-Ryeong Park, Eun Ha Namkung
Disability and Health Journal.2024; 17(2): 101543. CrossRef
Increased Risk of Dementia Following a Diagnosis of Hearing Impairment: A South Korean Nationwide Cohort Study
Minah Park, Sung-In Jang, Kyungduk Hurh, Eun-Cheol Park, Seung Hoon Kim
Journal of Alzheimer's Disease.2024; 97(2): 679. CrossRef
Risk of fracture among patients with spinal cord injury: A nationwide cohort study in South Korea
Seonghye Kim, Bongseong Kim, Kyung-Do Han, Junhee Park, Jung Eun Yoo, Hea Lim Choi, Won Hyuk Chang, In Young Cho, Dong Wook Shin
Bone.2024; 183: 117093. CrossRef
Desafios para inclusão de escolares com deficiência em um estado do brasileiro
Paola Regina Martins Bruno, Graziane Pacini Rodrigues, Damarys Paula Alves Alvim, Francisco Winter dos Santos Figueiredo, Janeisi de Lima Meira, Andreia de Bem Machado, Gabriel Martins Cabral, Fernando Rodrigues Peixoto Quaresma
Cuadernos de Educación y Desarrollo.2024; 16(4): e3840. CrossRef
Korean autistic persons facing systemic stigmatization from middle education schools: daily survival on the edge as a puppet
Wn-ho Yoon, JaeKyung Seo, Cheolung Je
Frontiers in Psychiatry.2024;[Epub] CrossRef
Disability acceptance and depressive symptoms: the moderating role of social support
Gum-Ryeong Park, Sujeong Park, Jinho Kim
Disability and Rehabilitation.2024; 46(26): 6424. CrossRef
Impact of a Service-Learning Program Using Soccer Training on the Emotional and Behavioral Problems of Children with Developmental Disabilities
Huan Meng, Yonghwan Kim, Kyujin Lee
Children.2024; 11(4): 467. CrossRef
Risk of Heart Disease in Patients With Amputation: A Nationwide Cohort Study in South Korea
Hea Lim Choi, Jung Eun Yoo, Miso Kim, Bongsung Kim, Junhee Park, Won Hyuk Chang, Heesun Lee, Kyungdo Han, Dong Wook Shin
Journal of the American Heart Association.2024;[Epub] CrossRef
Fracture Risk Among Stroke Survivors According to Poststroke Disability Status and Stroke Type
Dagyeong Lee, In Young Cho, Won Hyuk Chang, Jung Eun Yoo, Hea Lim Choi, Junhee Park, Dong Wook Shin, Kyungdo Han
Stroke.2024; 55(6): 1498. CrossRef
Disparities in the diagnosis and treatment of colorectal cancer among patients with disabilities
Ki Bae Kim, Dong Wook Shin, Kyoung Eun Yeob, So Young Kim, Joung-Ho Han, Seon Mee Park, Jong Heon Park, Jong Hyock Park
World Journal of Gastrointestinal Oncology.2024; 16(7): 2925. CrossRef
Increased Risk of Fracture after Traumatic Amputation: A Nationwide Retrospective Cohort Study
Hyeonjin Cho, Junhee Park, Bongseong Kim, Kyungdo Han, Hea Lim Choi, Dong Wook Shin
Healthcare.2024; 12(13): 1362. CrossRef
Trends in Physiotherapy Interventions and Medical Costs for Parkinson’s Disease in South Korea, 2011–2020
Dong-Woo Ryu, Jinse Park, Myung Jun Lee, Dallah Yoo, Sang-Myung Cheon
Journal of Movement Disorders.2024; 17(3): 270. CrossRef
COVID-19 and Neurodevelopmental Delays in Early Childhood: A Longitudinal Analysis of Developmental Outcomes in Korean Children
Youn Young Choi, Kyung-Shin Lee, Seul Gi Park, You Sun Kim, Jeehye Lee, Ho Kyung Sung, Myoung-hee Kim
Journal of Korean Medical Science.2024;[Epub] CrossRef
Risk of depression in amyotrophic lateral sclerosis: A nationwide cohort study in South Korea
Soonwook Kwon, Bongseong Kim, Kyung-Do Han, Wonyoung Jung, Eun Bin Cho, Dong Wook Shin, Ju-Hong Min
Journal of Psychiatric Research.2024; 178: 414. CrossRef
Association between glycemic status and all-cause mortality among individuals with dementia: a nationwide cohort study
Youn Huh, Kye-Yeung Park, Kyungdo Han, Jin-Hyung Jung, Yoon Jeong Cho, Hye Soon Park, Ga Eun Nam, Soo Lim
Alzheimer's Research & Therapy.2024;[Epub] CrossRef
The Association between Healthcare Satisfaction and Social Support and Stress, Depression, and Life Satisfaction in Female Caregivers: The Moderating Role of Dependence of a Sick Child
Jadranka Pavić, Mateja Krznar, Snježana Čukljek, Biserka Sedić, Štefanija Ozimec Vulinec, Irena Kovačević
International Journal of Environmental Research and Public Health.2024; 21(9): 1245. CrossRef
Comparison of the risk of noise-induced hearing loss between male police officers and male non-police officers: a nationwide cohort study using propensity score matching in South Korea
Woo-Ri Lee, Kyu-Tae Han, Ki-Bong Yoo, Jin-Ha Yoon
BMC Public Health.2024;[Epub] CrossRef
Retinal Vascular Occlusions After COVID-19 Vaccination in South Korea: A Nation-Wide Population-Based Study
Yeji Kim, Kyungdo Han, Jae Hui Kim
Ophthalmic Epidemiology.2024; : 1. CrossRef
Short-Term and Long-Term Risk of Diabetes Mellitus among Patients with Spinal Cord Injury: A Nationwide Retrospective Cohort Study
Seonghye Kim, Kyung-Do Han, Bongseong Kim, Ju-Hong Min, Won Hyuk Chang, In Young Cho, Dong Wook Shin
Healthcare.2024; 12(18): 1859. CrossRef
Widening disparities in the national prevalence of diabetes mellitus for people with disabilities in South Korea
I. Hwang, S.Y. Kim, Y.Y. Kim, J.H. Park
Public Health.2024; 226: 173. CrossRef
Increased Risk of Myocardial Infarction, Heart Failure, and Atrial Fibrillation After Spinal Cord Injury
Jung Eun Yoo, Miso Kim, Bongseong Kim, Heesun Lee, Won Hyuk Chang, Jeehyun Yoo, Kyungdo Han, Dong Wook Shin
Journal of the American College of Cardiology.2024; 83(7): 741. CrossRef
Beyond the Stereotype: Exploring Monetary Donations and Volunteerism Among People With Disabilities
Jonghwa Lee, Youngeun Son, Ha-Neul Kim
Nonprofit and Voluntary Sector Quarterly.2024;[Epub] CrossRef
Caregivers' Awareness and Behavior Impacting the Oral Health of Pediatric and Adolescent Patients with Disabilities
Haesong Kang, Namki Choi, Seonmi Kim
THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY.2024; 51(4): 459. CrossRef
Longitudinal association between disability and suicide mortality in Republic of Korea
Hwa-Young Lee, Dong Wook Shin, Kyung-Do Han, Ichiro Kawachi
International Journal of Epidemiology.2024;[Epub] CrossRef
Increased risk of Parkinson's disease amongst patients with age‐related macular degeneration and visual disability: A nationwide cohort study
Je Moon Yoon, Dong Hui Lim, Jinyoung Youn, Kyungdo Han, Bong Sung Kim, Wonyoung Jung, Yohwan Yeo, Dong Wook Shin, Don‐Il Ham
European Journal of Neurology.2023; 30(9): 2641. CrossRef
Increased risk of myocardial infarction in amyotrophic lateral sclerosis: A nationwide cohort study in South Korea
Soonwook Kwon, Bongseong Kim, Kyung-Do Han, Wonyoung Jung, Eun Bin Cho, Jeong Hoon Yang, Dong Wook Shin, Ju-Hong Min
Journal of the Neurological Sciences.2023; 454: 120829. CrossRef

Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis: Seunghee Jun, Hyunjin Park, Ui-Jeong Kim, Eun Jeong Choi, Hye Ah Lee, Bomi Park, Soon Young Lee, Sun Ha Jee, Hyesook Park; Epidemiol Health. 2023;45:e2023092. Published online October 16, 2023; DOI: https://doi.org/10.4178/epih.e2023092

20,852 View
664 Download
10 Web of Science
16 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis.

METHODS

Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis.

RESULTS

Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males.

CONCLUSIONS

Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.

Summary

Korean summary
본 연구는 코호트 연구를 기반으로 하여 음주의 수준에 따른 암 위험 연관성에 대해 체계적 문헌고찰(139편)과 메타분석(106편)을 수행하였다. 연구 결과, 음주와 암 위험 사이에 용량-반응 관계가 나타났으며, 소량의 음주는 암 유형에 따라 차이가 있었으나, 식도암, 대장암, 전립선암(남성), 유방암(여성)에서 암 위험과의 연관성이 있음을 발견했다. 따라서, 암 위험 측면에서 음주에 안전한 수준이 없음을 시사하며, 음주와 관련된 잠재적 피해를 완화하기 위해서는 음주 지침 강화와 같은 공중보건개입이 필요하다.

Key Message
The aim of this study was to assess the relationship between different levels of alcohol consumption and the risk of various cancer types through a systematic review and meta-analysis, providing insights into the ongoing debate about alcohol consumption and cancer causality. The findings support a dose-response relationship between alcohol consumption levels and cancer risk and the light alcohol consumption was associated with risks of esophageal, colorectal, prostate (male), and breast (female) cancer. These results emphasize the absence of a safe threshold for alcohol consumption in terms of cancer risk.

Citations

Citations to this article as recorded by

Unraveling the bidirectional link between cancer and dementia and the impact of cancer therapies on dementia risk: A systematic review and meta‐analysis
Liwei Ma, Edwin C. K. Tan, Benjamin Goudey, Liang Jin, Yijun Pan
Alzheimer's & Dementia.2025;[Epub] CrossRef
Associations of lifestyle factors with oral cancer risk: An umbrella review
Haobo Xu, Zhonglan Gao, Hairong Liu, Liya An, Ting Yang, Bojun Zhang, Guobin LIU, Dali Sun
Journal of Stomatology, Oral and Maxillofacial Surgery.2025; : 102234. CrossRef
Estudio bibliométrico de las publicaciones sobre cirugía pancreática realizadas por cirujanos españoles
Juan Jesús Rubio-García, Celia Villodre Tudela, Cándido Alcázar López, Silvia Carbonell Morote, Mariano Franco Campello, Paola Melgar Requena, Adrián Paredes Segura, José Manuel Ramia Ángel
Cirugía Española.2025;[Epub] CrossRef
Personalized Lifestyle Interventions for Prevention and Treatment of Obesity-Related Cancers: A Call to Action
Mohamad Motevalli, Fatima Cody Stanford
Cancers.2025; 17(8): 1255. CrossRef
Bibliometric study of publications on pancreatic surgery carried out by spanish surgeons
Juan Jesús Rubio-García, Celia Villodre Tudela, Cándido Alcázar López, Silvia Carbonell Morote, Mariano Franco Campello, Paola Melgar Requena, Adrián Paredes Segura, José Manuel Ramia Ángel
Cirugía Española (English Edition).2025;[Epub] CrossRef
Exploring genetic associations of Crohn’s disease and ulcerative colitis with extraintestinal cancers in European and East Asian populations
Chengdong Yu, Jiawei Xu, Siyi Xu, Lei Tang, Qinyuan Han, Xiaoqiang Zeng, Yanxiao Huang, Tenghua Yu, Zhengkui Sun
Frontiers in Immunology.2024;[Epub] CrossRef
The Impact of Tobacco Smoking and Alcohol Consumption on the Development of Gastric Cancers
Waku Hatta, Tomoyuki Koike, Naoki Asano, Yutaka Hatayama, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Kaname Uno, Akira Imatani, Atsushi Masamune
International Journal of Molecular Sciences.2024; 25(14): 7854. CrossRef
Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors
Jeanne E. Savage, Peter B. Barr, Tanya Phung, Younga H. Lee, Yingzhe Zhang, Vivia V. McCutcheon, Tian Ge, Jordan W. Smoller, Lea K. Davis, Jacquelyn Meyers, Bernice Porjesz, Danielle Posthuma, Travis T. Mallard, Sandra Sanchez-Roige
American Journal of Psychiatry.2024; 181(11): 1006. CrossRef
To Drink or Not to Drink? Investigating Alcohol’s Impact on Prostate Cancer Risk
Aris Kaltsas, Michael Chrisofos, Evangelos N. Symeonidis, Athanasios Zachariou, Marios Stavropoulos, Zisis Kratiras, Ilias Giannakodimos, Asterios Symeonidis, Fotios Dimitriadis, Nikolaos Sofikitis
Cancers.2024; 16(20): 3453. CrossRef
Factors associated with acquiring exercise habits through health guidance for metabolic syndrome among middle-aged Japanese workers: A machine learning approach
Jiawei Wan, Kyohsuke Wakaba, Takeshi Onoue, Kazuyo Tsushita, Yoshio Nakata
Preventive Medicine Reports.2024; 48: 102915. CrossRef
Development of an algorithm for identifying paraneoplastic ischemic stroke in association with lung, pancreatic, and colorectal cancer
Rebecca Kassubek, Marc-Andre G. R. Winter, Jens Dreyhaupt, Mona Laible, Jan Kassubek, Albert C. Ludolph, Jan Lewerenz
Therapeutic Advances in Neurological Disorders.2024;[Epub] CrossRef
Alimentación y cáncer
Carlos A. González Svatetz
FMC - Formación Médica Continuada en Atención Primaria.2024; 31(8): 403. CrossRef
Alcohol consumption and its association with cancer, cardiovascular, liver and brain diseases: a systematic review of Mendelian randomization studies
Naouras Bouajila, Cloé Domenighetti, Henri-Jean Aubin, Mickael Naassila
Frontiers in Epidemiology.2024;[Epub] CrossRef
Prévention et dépistage des cancers dans les rhumatismes inflammatoires chroniques
Elodie Mamou, Laetitia Morardet, Djaha Mogni, Bruno Fautrel, Laure Gossec
Revue du Rhumatisme.2024;[Epub] CrossRef
Global, regional, and national trends in gastric cancer burden: 1990-2021 and projections to 2040
Tao Zhang, Yiqun Zhang, Xiaofei Leng
Frontiers in Oncology.2024;[Epub] CrossRef
Alcohol Consumption and Breast and Ovarian Cancer Development: Molecular Pathways and Mechanisms
Francesca Fanfarillo, Brunella Caronti, Marco Lucarelli, Silvia Francati, Luigi Tarani, Mauro Ceccanti, Maria Grazia Piccioni, Loredana Verdone, Micaela Caserta, Sabrina Venditti, Giampiero Ferraguti, Marco Fiore
Current Issues in Molecular Biology.2024; 46(12): 14438. CrossRef

Original Articles

Risk of cancer, cardiovascular disease, thromboembolism, and mortality in patients with rheumatoid arthritis receiving Janus kinase inhibitors: a real-world retrospective observational study using Korean health insurance data: Hong Ki Min, Hyeongsu Kim, Ho Jin Jeong, Se Hee Kim, Hae-Rim Kim, Sang-Heon Lee, KunSei Lee, Soon-Ae Shin, Jong Heon Park; Epidemiol Health. 2023;45:e2023045. Published online April 15, 2023; DOI: https://doi.org/10.4178/epih.e2023045

10,756 View
341 Download
12 Web of Science
12 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
This study investigated whether Janus kinase inhibitors (JAKis) raise the risk of cardiovascular disease (CVD), venous thromboembolism (VTE), and cancer in patients with rheumatoid arthritis (RA).

METHODS

We conducted a real-world retrospective observational study using data obtained from the Korean National Health Insurance Service database. Two data sets were analyzed: tumor necrosis factor inhibitor (TNFi)/JAKi-naive RA patients (set 1) and all RA patients who used TNFis or JAKis (set 2). The incidence rate ratios (IRRs) and hazard ratios (HRs) for acute myocardial infarction (AMI), stroke, cardiovascular (CV)-related mortality, major adverse cardiovascular events (MACE), VTE, arterial thromboembolism (ATE), cancer, and all-cause mortality were compared between the JAKi and TNFi groups.

RESULTS

Set 1 included 1,596 RA patients (JAKi group: 645; TNFi group: 951), and set 2 included 11,765 RA patients (JAKi group: 2,498; TNFi group: 9,267). No adverse events (AEs) showed significantly higher IRRs in the JAKi groups than in the TNFi groups of sets 1 and 2. The HRs for MACE in the JAKi groups of sets 1 and 2 were 0.59 (95% confidence [CI], 0.35 to 0.99) and 0.80 (95% CI, 0.67 to 0.97), respectively. The JAKi group of set 2 showed a significantly higher risk of all-cause mortality (HR, 1.71; 95% CI, 1.32 to 2.20), but the other AEs did not demonstrate increased risks in the JAKi groups.

CONCLUSIONS

In this study, JAKis did not increase the risk of AMI, stroke, CV-related mortality, MACE, VTE, ATE, or cancer in Korean RA patients relative to TNFis.

Summary

Korean summary
1. 한국인 류마티스관절염 환자를 대상으로 한 실제임상자료 결과, JAK 억제제가 종양괴사인자 억제제에 비해 심혈관질환, 혈전증, 암 등의 심각한 부작용을 증가시키지는 않았다. 2. 본 연구를 토대로 한국인 대상자에서 JAK 억제제가 심혈관질환 등의 심각한 부작용을 증가시키는지에 대한 재평가가 필요하다.

Key Message
1. The real word-data based results showed that risks of MACE, thromboembolism, and cancers were not increased in Korean RA patients with JAK inhibitor when compared to Korean RA patients with TNF inhibitors. 2. Therefore, the risk of serious adverse events of JAK inhibitors in Korean population should be reconsidered and reassessed before adding black box warning of JAK inhibitors.

Citations

Citations to this article as recorded by

Cardiovascular, cancer, and infection risks of Janus kinase inhibitors in rheumatoid arthritis and ulcerative colitis: A nationwide cohort study
Yongtai Cho, Dongwon Yoon, Farzin Khosrow‐Khavar, Minkyo Song, Eun Ha Kang, Ju Hwan Kim, Ju‐Young Shin
Journal of Internal Medicine.2025; 297(4): 366. CrossRef
Safety of Janus kinase inhibitors in immune-mediated inflammatory diseases – a systematic literature review informing the 2024 update of an international expert consensus statement
Victoria Konzett, Josef S. Smolen, Peter Nash, Kevin Winthrop, Daniel Aletaha, Thomas Dörner, Roy Fleischmann, Yoshiya Tanaka, Jette Primdahl, Xenofon Baraliakos, Iain B. McInnes, Michael Trauner, Naveed Sattar, Maarten de Wit, Jan W. Schoones, Andreas Ke
Annals of the Rheumatic Diseases.2025;[Epub] CrossRef
Comparative safety of JAK inhibitors versus TNF or IL-17 inhibitors for cardiovascular disease and cancer in psoriatic arthritis and axial spondyloarthritis
Sizheng Steven Zhao, David Riley, Gema Hernandez, Uazman Alam
Clinical Therapeutics.2025; 47(4): 293. CrossRef
The Cardiovascular Safety of Tumour Necrosis Factor Inhibitors in Arthritic Conditions: A Structured Review with Recommendations
Jérôme Avouac, Hafid Ait-Oufella, Caroline Habauzit, Salim Benkhalifa, Bernard Combe
Rheumatology and Therapy.2025; 12(2): 211. CrossRef
Major adverse cardiovascular events or venous thromboembolism in patients with rheumatoid arthritis initiating biological or targeted synthetic disease-modifying antirheumatic drugs: a nationwide, population-based cohort study
Chung-Mao Kao, Yen-Ju Chen, Yi-Ming Chen, Der-Yuan Chen, Hsin-Hua Chen
Therapeutic Advances in Musculoskeletal Disease.2025;[Epub] CrossRef
Major Adverse Cardiovascular Events Related to JAK Inhibitors: A Disproportionality Analysis Using the WHO Global Individual Case Safety Database
Raffaella Di Napoli, Christophe Richez, Cristina Scavone, Allison Singier, Maxime Demorgues, Annamaria Mascolo, Annalisa Capuano, Francesco Salvo
Drug Safety.2025;[Epub] CrossRef
Multicenter evaluation of tofacitinib retention and safety in rheumatoid arthritis – why cardiovascular risk factors do not equate to overt risk
Anna Felis-Giemza, Mateusz Moskal, Krzysztof Proc, Zbigniew Guzera, Marcin Stajszczyk, Karolina Palej, Kornelia Chmurzyńska, Piotr Wiland, Krzysztof Batko, Bogdan Batko
Rheumatology.2024; 61(6): 414. CrossRef
Biologics Versus JAK Inhibitors. Part I: Cancer Risk. A Narrative Review
Miguel Mansilla-Polo, Daniel Morgado-Carrasco
Dermatology and Therapy.2024; 14(6): 1389. CrossRef
JAK inhibitor selectivity: new opportunities, better drugs?
Anniina Virtanen, Francesca Romana Spinelli, Jean Baptiste Telliez, John J. O’Shea, Olli Silvennoinen, Massimo Gadina
Nature Reviews Rheumatology.2024; 20(10): 649. CrossRef
Safety and Effectiveness of Baricitinib in Chinese Patients with Moderate-to-Severe Rheumatoid Arthritis: 24-Week Results from a Post-Marketing Safety Study
Chan-yuan Wu, Qian Wang, Jian Shi, Xiu-ying Zhang, Rong Du, Jie-ruo Gu, Qi-huan Liu, Jiao Yu, Jia-wei Xu, Yan-jie Zhang, Hao Zhu, Meng-tao Li, Xiao-feng Zeng
Rheumatology and Therapy.2023; 10(6): 1609. CrossRef
Comparative cardiovascular safety with janus kinase inhibitors and biological disease-modifying antirheumatic drugs as used in clinical practice: an observational cohort study from Sweden in patients with rheumatoid arthritis
Hannah Bower, Thomas Frisell, Daniela di Giuseppe, Benedicte Delcoigne, Johan Askling
RMD Open.2023; 9(4): e003630. CrossRef
Are JAKis more effective among elderly patients with RA, smokers and those with higher cardiovascular risk? A comparative effectiveness study of b/tsDMARDs in Sweden
Hannah Bower, Thomas Frisell, Daniela di Giuseppe, Benedicte Delcoigne, Ulf Lindström, Carl Turesson, Katerina Chatzidionysiou, Elisabet Lindqvist, Ann Knight, Helena Forsblad-d'Elia, Johan Askling
RMD Open.2023; 9(4): e003648. CrossRef

Changes in mental health service utilization before and during the COVID-19 pandemic: a nationwide database analysis in Korea: Kyoung Hoon Kim, Sang Min Lee, Minha Hong, Kyu-Man Han, Jong-Woo Paik; Epidemiol Health. 2023;45:e2023022. Published online February 14, 2023; DOI: https://doi.org/10.4178/epih.e2023022

13,064 View
315 Download
8 Web of Science
9 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
The present study examined the impact of the coronavirus disease 2019 (COVID-19) pandemic on mental health service utilization through a comparative analysis of nationwide data regarding inpatient care users, outpatient visits, emergency department (ED) visits, and admissions via the ED before and during the pandemic.

METHODS

Data from approximately 350,000 Koreans diagnosed with mental illness were analyzed in terms of hospitalization, outpatient visits, and ED visits between January 2018 and June 2021. An interrupted time series analysis was conducted to determine the significance of changes in mental health service utilization indicators.

RESULTS

The number of hospital admissions per patient decreased by 1.2% at the start of the pandemic and 0.7% afterward. The length of hospital stay increased by 1.8% at the outbreak of the pandemic, and then decreased by 20.2%. Although the number of outpatients increased, the number of outpatient visits per patient decreased; the number of outpatient visits for schizophrenia (3.4%) and bipolar disorder (3.5%) significantly decreased immediately post-outbreak. The number of ED visits per patient decreased both immediately post-outbreak and afterward, and ED visits for schizophrenia (19.2%), bipolar disorder (22.3%), and depression (17.4%) decreased significantly immediately post-outbreak. Admissions via the ED did not show a significant change immediately post-outbreak.

CONCLUSIONS

Mental health service utilization increased during the pandemic, but medical service use decreased overall, with a particularly significant decrease in ED utilization. As the pandemic worsened, the decline in outpatient visits became more pronounced among those with severe mental illness.

Summary

Korean summary
이 연구는 COVID-19 전후 정신질환 의료서비스 이용 변화를 분석하였다. 팬데믹 기간 중에 정신질환 의료서비스는 전반적으로 감소하였고, 특히 중증 정신질환의 외래 방문이 감소하였다. 따라서, 정신질환자의 진료 연속성을 보장하기 위한 조치가 요구된다.

Key Message
This study examined the impact of the COVID-19 pandemic on mental health service utilization. The mental health service utilization decreased overall after the outbreak of COVID-19, especially outpatient visits for severe mental illness significantly decreased. Therefore, countermeasures are needed to maintain the continuity of care.

Citations

Citations to this article as recorded by

A population-based cohort to investigate the impact of COVID-19 on socioeconomic inequalities in mental health care in Italy (CoMeH): study protocol
Alessio Petrelli, Massimiliano Aragona, Roberta Ciampichini, Anteo Di Napoli, Valeria Fano, Sara Leone, Martina Pacifici, Claudio Rosini, Caterina Silvestri, Alberto Zucchi, Martina Ventura
Social Psychiatry and Psychiatric Epidemiology.2025;[Epub] CrossRef
Factors Associated with Leaving Ambulatory Psychiatric Treatment in a Large, Academic Health System During the COVID-19 Pandemic
Nathaniel A. Sowa, Xiaoming Zeng
Psychiatric Quarterly.2025;[Epub] CrossRef
Adult Mental Health Presentations to Emergency Departments in Victoria, Australia between January 2018 and October 2020: Changes Associated with COVID-19 Pandemic Public Health Restrictions
Jackson Newberry-Dupé, Wanyu Chu, Simon Craig, Rohan Borschmann, Gerard O’Reilly, Paul Yates, Glenn Melvin, Kylie King, Harriet Hiscock
Psychiatric Quarterly.2024; 95(1): 33. CrossRef
Incidence of Panic Disorder Diagnoses After Celebrity Disclosures of Panic Disorder in South Korea
Ga Eun Kim, Min-Woo Jo, Young Eun Kim, Seok-Jun Yoon, Yong-Wook Shin
JAMA Network Open.2024; 7(7): e2420934. CrossRef
Stigma Experience and Mental Health of Vulnerable Groups: Focusing on the COVID-19 Period
Sung Moon Choi, Jong-Woo Paik, Myung Jae Paik, Jin Hee Hyun, Sung Eun You, Ah Rah Lee, Sang Min Lee
Journal of Korean Neuropsychiatric Association.2024; 63(4): 225. CrossRef
Changes in psychiatric disorder incidence patterns during the COVID-19 pandemic in Korea: a study using the nationwide universal health insurance data
Changwoo Han, Juho Choi, Hoyeon Jang, Hwa-Young Lee, Tarik Benmarhnia, Juhwan Oh
BMC Psychiatry.2024;[Epub] CrossRef
The impact of the COVID-19 pandemic on access to mental health services and socioeconomic inequalities in Italy
Alessio Petrelli, Martina Ventura, Roberta Ciampichini, Anteo Di Napoli, Valeria Fano, Christian Napoli, Martina Pacifici, Claudio Rosini, Caterina Silvestri, Fabio Voller, Alberto Zucchi, Massimiliano Aragona
Frontiers in Psychiatry.2024;[Epub] CrossRef
Trends in telemedicine utilization for mental illness during the COVID-19 pandemic: an analysis of a nationwide database in Korea
Kyoung Hoon Kim, Sang Min Lee, Minha Hong, Kyu-Man Han, Jong-Woo Paik
BMC Psychiatry.2023;[Epub] CrossRef
Admissions to psychiatric inpatient services and use of coercive measures in 2020 in a Swiss psychiatric department: An interrupted time-series analysis
Alexandre Wullschleger, Leonel Gonçalves, Maya Royston, Othman Sentissi, Julia Ambrosetti, Stefan Kaiser, Stéphanie Baggio, Jahida Gulshan
PLOS ONE.2023; 18(7): e0289310. CrossRef

Parental concerns about COVID-19 vaccine safety and hesitancy in Korea: implications for vaccine communication: Hye-Kyung Cho, Hyunju Lee, Young June Choe, Shinkyeong Kim, Sujin Seo, Jiwon Moon, Eun Hwa Choi, Geun-Yong Kwon, Jee Yeon Shin, Sang-Yoon Choi, Mi Jin Jeong, Myoungsoon You; Epidemiol Health. 2023;45:e2023004. Published online December 13, 2022; DOI: https://doi.org/10.4178/epih.e2023004

10,177 View
169 Download
7 Web of Science
8 Crossref

Abstract Summary PDF

Abstract

OBJECTIVES
Vaccination is one of the most important strategies to contain the spread of coronavirus disease 2019 (COVID-19). Vaccination in children is dependent on their parents, making it important to understand parents’ awareness and attitudes toward vaccines in order to devise strategies to raise vaccination rates in children.

METHODS

A web-based nationwide survey was conducted among Korean parents of 7-year-old to 18-year-old children in August 2021 to estimate parents’ intention to vaccinate their children against COVID-19 and identify key factors affecting parental acceptance and hesitancy through regression analysis.

RESULTS

Approximately 56.4% (575/1,019) were willing to vaccinate their children against COVID-19. Contributing factors to COVID-19 vaccine hesitancy were being a mother (adjusted odds ratio [aOR], 0.36; 95% confidence interval [CI], 0.25 to 0.52), a lower education level (aOR, 0.83; 95% CI, 0.70 to 0.97), hesitancy to other childhood vaccines (aOR, 0.78; 95% CI, 0.64 to 0.96), and refusal to vaccinate themselves (aOR, 0.08; 95% CI, 0.02 to 0.20). Having older children (aOR, 1.20; 95% CI, 1.13 to 1.28), trusting the child’s doctor (aOR, 1.19; 95% CI, 1.07 to 1.32), positive perceptions of the COVID-19 vaccine’s effectiveness (aOR, 2.60; 95% CI, 1.90 to 3.57) and perceiving the COVID-19 vaccine as low-risk (aOR, 1.68; 95% CI, 1.27 to 2.24) were associated with COVID-19 vaccine acceptance. Concerns about adverse reactions were the most common cause of hesitancy.

CONCLUSIONS

Providing parents with accurate and reliable information on vaccine effectiveness and safety is important to increase COVID-19 vaccine uptake in children. Differential or targeted approaches to parents according to gender, age, and their children’s age are necessary for effective communication about vaccination in children.

Summary

Korean summary
부모에게 백신 효과와 안전성에 대한 정확하고 믿을만한 정보를 제공하는 것이 소아 코로나19 백신 접종률을 높이는데 중요하다. 자녀의 백신 접종에 대한 의사소통을 효율적으로 하기 위해서는 부모의 성별과 연령, 자녀의 연령을 고려한 차별적인 접근 방법이 필요하다.

Key Message
To improve COVID-19 vaccine uptake in children, it's crucial to provide parents with reliable and precise information about vaccine safety and effectiveness. Targeted communication strategies that consider factors such as the age of the parents and their children, as well as gender, may be necessary to effectively convey this information.

Citations

Citations to this article as recorded by

Safety of BNT162b2 mRNA COVID-19 vaccine in children with chronic kidney disease: a national population study from South Korea
Young June Choe, Yo-Han Ahn, Eunsun Gwak, Eunseo Jo, Jinseob Kim, Seung-Ah Choe
Pediatric Nephrology.2024; 39(2): 625. CrossRef
Assessing the determinants of influenza and COVID-19 vaccine co-administration decisions in the elderly
Seunghyun Lewis Kwon, So-Yeon Kim, Minju Song, Hyung-Min Lee, Seon-Hwa Ban, Mi-Soon Lee, Hyesun Jeong
Human Vaccines & Immunotherapeutics.2024;[Epub] CrossRef
Descriptive cross-sectional study to evaluate perception, attitude, and practice of parents regarding COVID-19 vaccination in children 10–12 years of age—A step toward prevention of future COVID-19 outbreaks in India
Vivek Mehta, Deep Inder, Pawan Kumar, Anupma Raheja
Journal of Family Medicine and Primary Care.2024; 13(5): 2104. CrossRef
Comparative safety of monovalent and bivalent mRNA COVID-19 booster vaccines in adolescents aged 12 to 17 years in the Republic of Korea
Mijeong Ko, Seontae Kim, Seok-Kyoung Choi, Seung Hwan Shin, Yeon-Kyeng Lee, Yunhyung Kwon
Osong Public Health and Research Perspectives.2024; 15(4): 364. CrossRef
Pediatric asthma and COVID-19 vaccination: unveiling patterns of hesitancy and acceptance
Marzieh Tavakol, Saber Gharagozlou, Mohammad Abbasi, Zahra Zamani, Mohammad Gharagozlou
Therapeutic Advances in Vaccines and Immunotherapy.2024;[Epub] CrossRef
Vaccine Hesitancy and Its Epistemic Antecedents: A Meta-Analysis
Emily A. Andrews, Nathan Walter, Yotam Ophir, Dror Walter, Christiana L. Robbins
Health Communication.2024; : 1. CrossRef
Willingness and hesitancy of parents to vaccinate against COVID-19 their children ages 6 months to 4 years with frail conditions in Italy
Grazia Miraglia del Giudice, Giorgia Della Polla, Mario Postiglione, Italo Francesco Angelillo
Frontiers in Public Health.2023;[Epub] CrossRef
Associations between Socio-Demographic Characteristics and Maternal Attitudes towards Childhood Vaccination in Cyprus—A Cross-Sectional Survey
Maria Kyprianidou, Georgia Fakonti, Eleana Tzira, Magdalini Pylli, Konstantinos Giannakou
COVID.2023; 3(7): 1042. CrossRef

Korea Seroprevalence Study of Monitoring of SARS-COV-2 Antibody Retention and Transmission (K-SEROSMART): findings from national representative sample: Jina Han, Hye Jin Baek, Eunbi Noh, Kyuhyun Yoon, Jung Ae Kim, Sukhyun Ryu, Kay O Lee, No Yai Park, Eunok Jung, Sangil Kim, Hyukmin Lee, Yoo-Sung Hwang, Jaehun Jung, Hun Jae Lee, Sung-il Cho, Sangcheol Oh, Migyeong Kim, Chang-Mo Oh, Byengchul Yu, Young-Seoub Hong, Keonyeop Kim, Sun Jae Jung, Mi Ah Han, Moo-Sik Lee, Jung-Jeung Lee, Young Hwangbo, Hyeon Woo Yim, Yu-Mi Kim, Joongyub Lee, Weon-Young Lee, Jae-Hyun Park, Sungsoo Oh, Heui Sug Jo, Hyeongsu Kim, Gilwon Kang, Hae-Sung Nam, Ju-Hyung Lee, Gyung-Jae Oh, Min-Ho Shin, Soyeon Ryu, Tae-Yoon Hwang, Soon-Woo Park, Sang Kyu Kim, Roma Seol, Ki-Soo Park, Su Young Kim, Jun-wook Kwon, Sung Soon Kim, Byoungguk Kim, June-Woo Lee, Eun Young Jang, Ah-Ra Kim, Jeonghyun Nam, The Korea Community Health Survey Group, Soon Young Lee, Dong-Hyun Kim; Epidemiol Health. 2023;45:e2023075. Published online August 17, 2023; DOI: https://doi.org/10.4178/epih.e2023075

10,597 View
232 Download
7 Web of Science
7 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
We estimated the population prevalence of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including unreported infections, through a Korea Seroprevalence Study of Monitoring of SARS-CoV-2 Antibody Retention and Transmission (K-SEROSMART) in 258 communities throughout Korea.

METHODS

In August 2022, a survey was conducted among 10,000 household members aged 5 years and older, in households selected through two stage probability random sampling. During face-to-face household interviews, participants self-reported their health status, COVID-19 diagnosis and vaccination history, and general characteristics. Subsequently, participants visited a community health center or medical clinic for blood sampling. Blood samples were analyzed for the presence of antibodies to spike proteins (anti-S) and antibodies to nucleocapsid proteins (anti-N) SARS-CoV-2 proteins using an electrochemiluminescence immunoassay. To estimate the population prevalence, the PROC SURVEYMEANS statistical procedure was employed, with weighting to reflect demographic data from July 2022.

RESULTS

In total, 9,945 individuals from 5,041 households were surveyed across 258 communities, representing all basic local governments in Korea. The overall population-adjusted prevalence rates of anti-S and anti-N were 97.6% and 57.1%, respectively. Since the Korea Disease Control and Prevention Agency has reported a cumulative incidence of confirmed cases of 37.8% through July 31, 2022, the proportion of unreported infections among all COVID-19 infection was suggested to be 33.9%.

CONCLUSIONS

The K-SEROSMART represents the first nationwide, community-based seroepidemiologic survey of COVID-19, confirming that most individuals possess antibodies to SARS-CoV-2 and that a significant number of unreported cases existed. Furthermore, this study lays the foundation for a surveillance system to continuously monitor transmission at the community level and the response to COVID-19.

Summary

Korean summary
인구집단을 기반으로 하여 대표성 있는 표본을 추출하여 COVID-19 항체유병률 조사를 전국적으로 수행함으로 지역사회 단위에서 지속적으로 모니터링할 수 있는 COVID-19 감시체계 구축의 기반을 마련하였다. 2022년 8월 우리나라 국민의 대부분이 COVID-19에 대한 항체를 보유하고 있었고 인구 3명 중 1명은 미확진 감염자로 추정되었다.

Key Message
The K-SEROSMART represents the first nationwide, community-based seroepidemiologic survey of COVID-19. In August 2022, most of the Korean people had antibodies to COVID-19, and one in three people was estimated to have an unreported infection. This study lays the foundation for a surveillance system to continuously monitor transmission at the community level and the response to COVID-19.

Citations

Citations to this article as recorded by

Modeling vaccination prioritization strategies for post-pandemic COVID-19 in the Republic of Korea accounting for under-reporting and age-structure
Geunsoo Jang, Jihyeon Kim, Robin N. Thompson, Hyojung Lee
Journal of Infection and Public Health.2025; 18(4): 102688. CrossRef
Limitations of neutralizing antibody titers in COVID-19 vaccine efficacy trials and a call for additional correlates of protection
Young Hoon Hwang, Dal-Hee Min, Wan Beom Park
Human Vaccines & Immunotherapeutics.2025;[Epub] CrossRef
Infection-mediated immune response in SARS-CoV-2 breakthrough infection and implications for next-generation COVID-19 vaccine development
Sho Miyamoto, Tadaki Suzuki
Vaccine.2024; 42(6): 1401. CrossRef
Changes in the intrinsic severity of severe acute respiratory syndrome coronavirus 2 according to the emerging variant: a nationwide study from February 2020 to June 2022, including comparison with vaccinated populations
Boyeong Ryu, Eunjeong Shin, Dong Hwi Kim, HyunJu Lee, So Young Choi, Seong-Sun Kim, Il-Hwan Kim, Eun-Jin Kim, Sangwon Lee, Jaehyun Jeon, Donghyok Kwon, Sungil Cho
BMC Infectious Diseases.2024;[Epub] CrossRef
Seroprevalence of SARS-CoV-2 infection in pediatric patients in a tertiary care hospital setting
Ploy Pattanakitsakul, Chanya Pongpatipat, Chavachol Setthaudom, Mongkol Kunakorn, Thiantip Sahakijpicharn, Anannit Visudtibhan, Nopporn Apiwattanakul, Surapat Assawawiroonhakarn, Uthen Pandee, Chonnamet Techasaensiri, Sophida Boonsathorn, Sujittra Chaisav
PLOS ONE.2024; 19(9): e0310860. CrossRef
Realistic Estimation of COVID-19 Infection by Seroprevalence Surveillance of SARS-CoV-2 Antibodies: An Experience From Korea Metropolitan Area From January to May 2022
In Hwa Jeong, Jong-Hun Kim, Min-Jung Kwon, Jayoung Kim, Hee Jin Huh, Byoungguk Kim, Junewoo Lee, Jeong-hyun Nam, Eun-Suk Kang
Journal of Korean Medical Science.2024;[Epub] CrossRef
COVID-19 Vaccination Recommendations for 2024–2025 in Korea
Wan Beom Park, Young Hoon Hwang, Ki Tae Kwon, Ji Yun Noh, Sun Hee Park, Joon Young Song, Eun Ju Choo, Min Joo Choi, Jun Yong Choi, Jung Yeon Heo, Won Suk Choi
Infection & Chemotherapy.2024; 56(4): 453. CrossRef

National trends and projection of chronic kidney disease incidence according to etiology from 1990 to 2030 in Iran: a Bayesian age-period-cohort modeling study: Fatemeh Shahbazi, Amin Doosti-Irani, Alireza Soltanian, Jalal Poorolajal; Epidemiol Health. 2023;45:e2023027. Published online February 17, 2023; DOI: https://doi.org/10.4178/epih.e2023027

8,833 View
212 Download
6 Web of Science
7 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
Chronic kidney disease (CKD) is a major public health problem worldwide. Predicting CKD incidence rates and case numbers at the national and global levels is vital for planning CKD prevention programs.

METHODS

Data on CKD incidence rates and case numbers in Iran from 1990 to 2019 were extracted from the Global Burden of Disease online database. The average annual percentage change was computed to determine the temporal trends in CKD age-standardized incidence rates from 1990 to 2019. A Bayesian age-period-cohort model was used to predict the CKD incidence rate and case numbers through 2030.

RESULTS

Nationally, CKD cases increased from 97,300 in 1990 to 315,500 in 2019. The age-specific CKD incidence rate increased from 168.52 per 100,000 to 382.98 per 100,000 during the same period. Between 2020 and 2030, the number of CKD cases is projected to rise to 423,300. The age-specific CKD incidence rate is projected to increase to 469.04 in 2030 (95% credible interval, 399.20 to 538.87). In all age groups and etiological categories, the CKD incidence rate is forecasted to increase by 2030.

CONCLUSIONS

CKD case numbers and incidence rates are anticipated to increase in Iran through 2030. The high level of CKD incidence in people with diabetes mellitus, hypertension, and glomerulonephritis, as well as in older people, suggests a deficiency of attention to these populations in current prevention plans and highlights their importance in future programs for the national control of CKD.

Summary

Key Message
Based on our findings, it is predicted that the number of chronic kidney patients in Iran will reach 423,300 people by 2030. Additionally, the age-specific incidence rate of chronic kidney disease (CKD) is projected to increase to 469.04 in the same year. The CKD incidence rate is forecasted to increase by 2030 in all age groups and etiological categories, including type 1 diabetes mellitus, type 2 diabetes mellitus, hypertension, glomerulonephritis, and other causes.

Citations

Citations to this article as recorded by

Nationwide trends and incidence of blindness in patients with diabetic retinopathy identified using an age-period-cohort analysis
Ju-Yeun Lee, Kunho Bae, Sangjun Lee, Sue K. Park
Eye.2025; 39(1): 118. CrossRef
Global, regional, and national burden of chronic kidney disease and its underlying etiologies from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021
Ling Deng, Shujin Guo, Yuping Liu, Yaojia Zhou, Youren Liu, Xiaoxia Zheng, Xijie Yu, Ping Shuai
BMC Public Health.2025;[Epub] CrossRef
Application progress of bio-manufacturing technology in kidney organoids
Runqi Mao, Junming Zhang, Haoxiang Qin, Yuanyuan Liu, Yuxin Xing, Wen Zeng
Biofabrication.2025; 17(2): 022007. CrossRef
Supporting Caregivers of Hemodialysis Patients: Applying the 5-A Self-management Model to Alleviate Caregiver Burden
Zahra Zarmohammadi, Marzieh Khatooni, Mehdi Ranjbaran, Seyedeh Zahra Hosseinigolafshani
Journal of Nursing and Midwifery Sciences.2024;[Epub] CrossRef
Improving Drug- and Disease-related Knowledge of Patients with Chronic Kidney Disease: Randomized Controlled Trial from a Sri Lankan Outpatient Clinic
Dilmi Wickramasinghe, Catherine Lynch, Judith Coombes, Shaluka Jayamanne, Shamila De Silva
Asian Journal of Pharmaceutical Research and Health Care.2024; 16(2): 208. CrossRef
Global forecasting of chronic kidney disease mortality rates and numbers with the generalized additive model
Fatemeh Shahbazi, Amin Doosti-Irani, Alireza Soltanian, Jalal Poorolajal
BMC Nephrology.2024;[Epub] CrossRef
Exploring the Lived Experiences of Family Caregivers Who Provided End-of-Life Care to Hemodialysis Patients: A Phenomenological Study in Iran
Sakineh Moghaddam Zeabadi, Ali Razaghpoor, Seyedehzahra Hosseinigolafshani
Jundishapur Journal of Chronic Disease Care.2024;[Epub] CrossRef

COVID-19: Health Statistics

Changes in the management of hypertension, diabetes mellitus, and hypercholesterolemia in Korean adults before and during the COVID-19 pandemic: data from the 2010-2020 Korea National Health and Nutrition Examination Survey: Yoonjung Kim, Suyeon Park, Kyungwon Oh, Hongseok Choi, Eun Kyeong Jeong; Epidemiol Health. 2023;45:e2023014. Published online February 1, 2023; DOI: https://doi.org/10.4178/epih.e2023014

9,643 View
183 Download
6 Web of Science
7 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
This study aimed to analyze the changes in chronic disease management indicators, including hypertension, diabetes mellitus, and hypercholesteremia, from 2010-2020 and before (2019) and during (2020) the coronavirus disease 2019 (COVID-19) pandemic.

METHODS

This study included 58,504 individuals aged ≥30 years who participated in the Korea National Health and Nutrition Examination Survey 2010-2020. Trends in the prevalence, awareness, treatment, and control of chronic diseases and the difference in those between before and during the COVID-19 pandemic were analyzed using the SAS program PROC SURVEYREG.

RESULTS

From 2010-2020, the awareness, treatment, and control in adults aged ≥30 years for hypertension and hypercholesterolemia continuously improved, whereas no significant change in the management indicators of diabetes mellitus was observed. The prevalence of hypertension, diabetes mellitus, and hypercholesterolemia in men increased from before to during the COVID- 19 pandemic. However, there was no significant change in the management indicators of hypertension and diabetes mellitus in men and women, and the awareness, treatment, and control rates for hypercholesterolemia increased by 5.5%p, 6.9%p, and 4.1%p respectively.

CONCLUSIONS

In 2020, the first year of the COVID-19 pandemic, the prevalence of hypertension, diabetes mellitus, and hypercholesterolemia increased, but the management indicators of the chronic diseases did not significantly deteriorate. Considering the ongoing COVID-19 pandemic, it is necessary to monitor changes in chronic disease management indicators and to develop efficient and accessible chronic disease prevention and management programs.

Summary

Korean summary
국민건강영양조사 자료를 분석한 결과 11년간(2010-2020년) 성인의 고혈압, 고콜레스테롤혈증 인지율, 치료율, 치료자 중 조절률은 개선된 반면 당뇨병은 변화가 없었다. 코로나19 유행 전(2019년)·후(2020년) 비교시 남자에서 고혈압, 당뇨병, 고콜레스테롤혈증 유병률이 증가했다. 그러나 고혈압, 당뇨병 관리지표는 변화가 없었고, 고콜레스테롤혈증 관리지표만 개선되었다.

Key Message
The rates of awareness, treatment, and control in adults aged ≥30 years for hypertension and hypercholesterolemia continuously improved, whereas no significant change in the management indicators of diabetes mellitus was observed over the past 11 years (2010-2020). The prevalence of hypertension, diabetes mellitus, and hypercholesterolemia in men increased from before (2019) to during (2020) the COVID-19 pandemic. However, there was no significant change in the management indicators of hypertension and diabetes mellitus in men and women, and that of hypercholesterolemia improved.

Citations

Citations to this article as recorded by

Korea Hypertension Fact Sheet 2024: nationwide population-based analysis with a focus on young adults
Hyeon Chang Kim, Hokyou Lee, Hyeok-Hee Lee, Song Vogue Ahn, Ju-Mi Lee, Dae Young Cheon, Jong Hyun Jhee, Minjae Yoon, Min-Ho Shin, JoonNyung Heo, Eunji Kim, Seung Won Lee, Jaeyong Lee, Yeon Woo Oh, Jooeun Jeon, Minsung Cho, Dasom Son, Na Yeon Ahn
Clinical Hypertension.2025;[Epub] CrossRef
One-year post-acute COVID-19 syndrome and mortality in South Korea: a nationwide matched cohort study using claims data
Jung-Hyun Won, Yesol Hong, Siun Kim, Howard Lee
Frontiers in Public Health.2024;[Epub] CrossRef
Impact of the COVID-19 Pandemic on Obesity, Metabolic Parameters and Clinical Values in the South Korean Adult Population
Anna Kim, Eun-yeob Kim, Jaeyoung Kim
Journal of Clinical Medicine.2024; 13(10): 2814. CrossRef
Effects of the COVID-19 Pandemic on the Medical Use of Elderly Patients with Hypertension: A Nationwide Cohort Study in Korea
Eunbyul Cho, Sujeong Han, Jae-ryun Lee, Hyejin Lee, Bumjo Oh
Korean Journal of Family Medicine.2024; 45(5): 283. CrossRef
Socioeconomic inequalities in the prevalence, non-awareness, non-treatment, and non-control of diabetes among South Korean adults in 2021
Seongju Kim, Dong Jun Kim, Hooyeon Lee, Dong Keon Yon
PLOS ONE.2024; 19(11): e0313988. CrossRef
Topic Modeling-Based Analysis of News Keywords Related to Patients with Diabetes during the COVID-19 Pandemic
Jeong-Won Han, Jung Min Kim, Hanna Lee
Healthcare.2023; 11(7): 957. CrossRef
Molecular Mechanisms Responsible for Diabetogenic Effects of COVID-19 Infection—Induction of Autoimmune Dysregulation and Metabolic Disturbances
Barbara Grubišić, Luka Švitek, Klara Ormanac, Dea Sabo, Ivica Mihaljević, Ines Bilić-Ćurčić, Tea Omanović Omanović Kolarić
International Journal of Molecular Sciences.2023; 24(14): 11576. CrossRef

Original Articles

Associations of the magnesium depletion score and magnesium intake with diabetes among US adults: an analysis of the National Health and Nutrition Examination Survey 2011-2018: Zhong Tian, Shifang Qu, Yana Chen, Jiaxin Fang, Xingxu Song, Kai He, Kexin Jiang, Xiaoyue Sun, Jianyang Shi, Yuchun Tao, Lina Jin; Epidemiol Health. 2024;46:e2024020. Published online January 10, 2024; DOI: https://doi.org/10.4178/epih.e2024020

8,410 View
155 Download
5 Web of Science
6 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
The magnesium depletion score (MDS) is considered more reliable than traditional approaches for predicting magnesium deficiency in humans. We explored the associations of MDS and dietary magnesium intake with diabetes.

METHODS

We obtained data from 18,853 participants in the National Health and Nutrition Examination Survey 2011-2018. Using multivariate regression and stratified analysis, we investigated the relationships of both MDS and magnesium intake with diabetes. To compute prevalence ratios (PRs), we employed modified Poisson or log-binomial regression. We characterized the non-linear association between magnesium intake and diabetes using restricted cubic spline analysis.

RESULTS

Participants with MDS ≥2 exhibited a PR of 1.26 (95% confidence interval [CI], 1.19 to 1.34) for diabetes. Per-standard deviation (SD) increase in dietary magnesium intake was associated with a lower prevalence of diabetes (PR, 0.91; 95% CI, 0.87 to 0.96). Subgroup analyses revealed a positive association between MDS ≥2 and diabetes across all levels of dietary magnesium intake, including the lowest (PR, 1.35; 95% CI, 1.18 to 1.55), middle (PR, 1.23; 95% CI, 1.12 to 1.35), and highest tertiles (PR, 1.25; 95% CI, 1.13 to 1.37; pinteraction<0.001). Per-SD increase in magnesium intake was associated with lower diabetes prevalence in participants with MDS <2 (PR, 0.92; 95% CI, 0.87 to 0.98) and those with MDS ≥2 (PR, 0.91; 95% CI, 0.84 to 0.98; pinteraction=0.030).

CONCLUSIONS

MDS is associated with diabetes, particularly among individuals with low magnesium intake. Adequate dietary magnesium intake may reduce diabetes risk, especially in those with high MDS.

Summary

Key Message
The relationship between magnesium intake and risk is currently understudied in the field of diabetes prevention. The study found that magnesium deficiency is associated with diabetes risk, especially in people with low magnesium intake. Dietary magnesium supplementation may reduce risk and provide a new strategy for diabetes prevention. This study fills this knowledge gap and is important for scientific understanding of diabetes pathogenesis and epidemiological prevention and control.

Citations

Citations to this article as recorded by

Magnesium Depletion Score and Mortality in Individuals with Metabolic Dysfunction Associated Steatotic Liver Disease over a Median Follow-Up of 26 Years
Lei Fan, Xiangzhu Zhu, Xinyuan Zhang, Shakirat Salvador, Xuehong Zhang, Martha J. Shrubsole, Manhal J. Izzy, Qi Dai
Nutrients.2025; 17(2): 244. CrossRef
Higher magnesium depletion score increases the risk of all‑cause and cardiovascular mortality in US adults with diabetes
Hao Zhang, Liping Kuang, Qiang Wan, Amirmohammad Khalaji
PLOS ONE.2025; 20(1): e0314298. CrossRef
Magnesium Matters: A Comprehensive Review of Its Vital Role in Health and Diseases
Ghizal Fatima, Andrej Dzupina, Hekmat B Alhmadi, Aminat Magomedova, Zainab Siddiqui, Ammar Mehdi, Najah Hadi
Cureus.2024;[Epub] CrossRef
Magnesium depletion score and depression: a positive correlation among US adults
Wei Zhao, Hai Jin
Frontiers in Public Health.2024;[Epub] CrossRef
Magnesium depletion score and gout: insights from NHANES data
Xu Cao, Haixia Feng, Huijie Wang
Frontiers in Nutrition.2024;[Epub] CrossRef
Association between magnesium depletion score and the prevalence of kidney stones in the low primary income ratio: a cross-sectional study of NHANES 2007–2018
Jiahao Wang, Yunfei Xiao, Yaqing Yang, Shan Yin, Jianwei Cui, Ke Huang, Jia Wang, Yunjin Bai
International Journal of Surgery.2024; 110(12): 7636. CrossRef

Body mass index and prevalence of metabolic syndrome among Korean adults before and after the COVID-19 outbreak: a retrospective longitudinal study: Joo-Eun Jeong, Hoon-Ki Park, Hwan-Sik Hwang, Kye-Yeung Park, Myoung-Hye Lee, Seon-Hi Shin, Nayeon Choi; Epidemiol Health. 2023;45:e2023081. Published online August 29, 2023; DOI: https://doi.org/10.4178/epih.e2023081

10,092 View
148 Download
3 Web of Science
6 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
Studies evaluating weight changes during the coronavirus disease 2019 (COVID-19) pandemic have yielded inconsistent results, and most of those studies were based on self-reported anthropometric measures. We investigated changes in body mass index (BMI), professionally measured waist circumference (WC), and metabolic syndrome components from before to during the pandemic in a sample of the adult population in Korea.

METHODS

This retrospective study included 1,118 male and female (age≥18 years) who underwent health checkups at a university medical center between January 1, 2016 and March 31, 2022. Changes in BMI, lifestyles, and metabolic syndrome components during the pandemic were analyzed using the paired t-test, McNemar test, generalized estimating equations, and repeated-measures analysis of variance.

RESULTS

Changes in body weight, BMI, and body fat percentage during the pandemic were not clinically significant. However, statistically significant results were found for decreased physical activity (p<0.001) and WC (p<0.001), and exacerbation of all metabolic syndrome components (except serum triglyceride levels). Moreover, the metabolic syndrome prevalence increased significantly from 20.2% to 31.2% during the pandemic (p<0.001). The prevalence of abdominal obesity and high fasting blood glucose levels also significantly increased from 2019 to 2021.

CONCLUSIONS

Metabolic syndrome, its components, and fat distribution worsened significantly after the implementation of social distancing and lockdowns, despite no clinically significant changes in body weight and BMI. Further studies on the post- pandemic period should investigate the long-term impact of social lockdowns on BMI and the prevalence of metabolic syndrome.

Summary

Korean summary
본 연구에서는 한국인 성인들의 코로나 팬대믹으로 인한 사회적 거리 두기, 봉쇄 정책 전 후의 체질량지수, 생활습관, 그리고 대사증후군과 그 구성 요소들의 변화를 건강검진을 통해 측정한 객관적인 지표의 변화를 통해 알아보고자 하였다. 연구 결과, 사회적 거리 두기 및 봉쇄 전후의 체질량지수와 체중은 유의미한 변화가 없었으나, 신체 활동량은 유의미하게 감소하였고, 체지방률, 허리둘레가 늘어났다. 그리고 중성지방을 제외하고 다른 대사증후군의 구성 요소인 혈압, 고밀도지단백 콜레스테롤, 공복혈당 지표는 악화되었다. 하위 그룹 분석에서 매년 검진을 시행 받은 대상자들 및 고혈압, 당뇨병, 이상지질혈증 약을 복용하지 않는 대상자들의 코로나-19 전후 연도별 대사 지표의 변화를 분석한 결과, 복부비만 유병률과 공복 혈당의 증가 양상이 뚜렷하였다.

Key Message
Although there was no significant change in BMI and weight, the prevalence of metabolic syndrome, abdominal obesity, and fasting blood glucose level prominently worsened after the implementation of social distancing and lockdowns. Such findings may indicate deterioration of insulin resistance during the COVID-19 pandemic. This study provides valuable information for healthcare professionals, policymakers, and the general public towards mitigating the negative consequences of the pandemic on metabolic health, regardless of weight gain.

Citations

Citations to this article as recorded by

Trends in the Incidence of Retinal Artery and Vein Occlusion Before and After COVID-19: A National Study in South Korea (2017-2022)
JIN CHO, NANG KYEONG LEE, JIN YEONG KIM, CHRISTOPHER SEUNGKYU LEE, SUK HO BYEON, SUNG SOO KIM, SEUNG WON LEE, YONG JOON KIM
American Journal of Ophthalmology.2025; 274: 101. CrossRef
Changes in body composition (muscle mass and adipose tissue) among adolescents aged 11–15 from Kraków during the COVID-19 pandemic
Paulina Artymiak, Magdalena Żegleń, Łukasz Kryst
Anthropological Review.2025; 87(4): 55. CrossRef
Impact of COVID-19 pandemic-related restrictive measures on overall mental and physical health and well-being, specific psychopathologies and emotional states in representative adult Greek population: Results from the largest multi-wave, online national s
Agorastos Agorastos, Christos Christogiannis, Dimitris Mavridis, Georgios Seitidis, Katerina M. Kontouli, Sofia Tsokani, Ourania Koutsiouroumpa, Kostantinos Tsamakis, Marco Solmi, Trevor Thompson, Christoph U. Correll, Elena Dragioti, Vasilios P. Bozikas
Psychiatry Research.2025; 348: 116479. CrossRef
Effects of Online-based Exercise on Body Composition and Muscular Function during the COVID-19 Pandemic
Juseong Lee, Jooeun Park, Hyunmin Kim, Geon Woo Lee, Junghoon Kim
The Asian Journal of Kinesiology.2024; 26(3): 74. CrossRef
Changes in food sufficiency among Korean adults in urban and rural areas during the COVID-19 pandemic: an analysis of the 7th and 8th Korea National Health and Nutrition Examination Survey
Sarang Jeong, Jin-Young Jeong, Sohyun Park
Epidemiology and Health.2024; 46: e2024045. CrossRef
A National trends in type 2 diabetes in South Korea, including the COVID-19 pandemic, 1998-2021: A nationally representative survey study
Yejun Son, Jaeyu Park, Hyejun Kim, Jiseung Kang, Masoud Rahmati, Selin Woo
Life Cycle.2024;[Epub] CrossRef

COVID-19: Special Article

Changes in health behaviors and obesity of Korean adolescents before and during the COVID-19 pandemic: a special report using the Korea Youth Risk Behavior Survey: Chang-Mo Oh, Yangha Kim, Jieun Yang, Sunhye Choi, Kyungwon Oh; Epidemiol Health. 2023;45:e2023018. Published online February 14, 2023; DOI: https://doi.org/10.4178/epih.e2023018

12,531 View
357 Download
6 Web of Science
6 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
This study aimed to investigate changes in health behaviors, including cigarette smoking, alcohol drinking, physical activity, dietary behaviors, and obesity, before and during the coronavirus disease 2019 (COVID-19) pandemic using the Korea Youth Risk Behavior Survey (KYRBS) database.

METHODS

KYRBS data from 2015 to 2021 were used in this study. Differences in health behaviors between before (pre-pandemic period: 2018-2019) and during (pandemic period: 2020-2021) the pandemic were examined. Differences were compared using linear regression and the chi-square test considering the complex survey design after adjusting for grade level.

RESULTS

The prevalence of current cigarette smoking and current alcohol drinking significantly decreased in both male and female students during the pandemic compared to the pre-pandemic period. However, the prevalence of obesity significantly increased in both male and female students during the same period. When examining physical activity and dietary behaviors closely related to obesity, fast food consumption increased and fruit consumption decreased during the pandemic in both male and female students, whereas no significant changes in physical activity were observed in either male or female students.

CONCLUSIONS

The deterioration of adolescent dietary behaviors and an increase in the prevalence of obesity can increase the future disease burden, and concerted efforts at the individual and national levels are needed to reduce obesity and promote healthy dietary behaviors.

Summary

Korean summary
이 연구는 한국 청소년건강행태조사자료(KYRBS)를 사용하여 코로나19 유행 전후의 우리나라 청소년들의 흡연, 음주, 신체활동, 식습관, 비만 등의 건강행태의 변화에 대하여 살펴보고자 하였다. 이 연구에서는 2015년부터 2021년까지의 청소년건강행태조사자료를 사용하여, 코로나19 유행 이전 (2018-2019년)과 코로나 유행 이후 (2020-2021년) 기간의 건강행태의 변화에 대하여 조사하였다. 학년레벨을 보정한 후, 복합표본설계를 고려하여 로지스틱 회귀분석과 카이제곱검정을 이용하여 코로나19 유행 이전 (2018-2019년)과 비교하여, 코로나 유행 이후 (2020-2021년) 기간의 건강행태의 변화가 있었는지에 대하여 확인하였다. 그 결과, 코로나19 유행 이전 (2018-2019년)과 비교하여, 코로나19 유행 기간(2020-2021년) 동안에 현재흡연율과 현재음주율이 유의하게 감소하였다. 그러나 동일한 기간 동안에 남학생과 여학생 모두에서 비만율이 유의하게 증가하였는데, 비만율과 관련된 신체활동 및 식습관에 대하여 살펴보았을 때, 신체활동에서는 유의한 변화가 없었던 반면, 남학생과 여학생 모두에서 패스트푸드 섭취는 증가하고 과일섭취가 감소한 것으로 나타났다. 따라서 코로나19 유행기간 동안 흡연율 및 음주율 등의 청소년 건강에 유익한 변화도 있었으나, 비만율도 같이 증가한 것을 확인할 수 있었다. 청소년기의 식습관의 악화 및 비만율의 증가는 미래 우리나라의 질병부담을 증가시킬 수 있기 때문에, 청소년의 비만율을 낮추고 건강한 식습관을 증진시키기 위한 개인 및 사회 차원의 노력이 필요하다.

Key Message
-The current cigarette smoking and current alcohol drinking rates significantly decreased among Korean adolescents during the pandemic period compared to the pre-pandemic period. -On the other hand, the obesity rate increased significantly especially among Korean male adolescents, which is accompanied by changes in dietary habits such as an increase in fast food intake and a decrease in fruit intake.

Citations

Citations to this article as recorded by

Unhealthy alcohol use: screening and behavioral counseling interventions
Wonyoung Jung, Seung-Won Oh, Se-Hong Kim, Soo Young Kim
Korean Journal of Family Medicine.2025; 46(1): 20. CrossRef
Changes in Adolescent Health Behavior and the Exacerbation of Economic Hardship During the COVID-19 Pandemic: A Cross-sectional Study From the Korea Youth Risk Behavior Survey
Chaeeun Kim, Haeun Lee, Kyunghee Jung-Choi, Hyesook Park
Journal of Preventive Medicine and Public Health.2024; 57(1): 18. CrossRef
Effects of changes in daily life attributed to COVID-19 on allergic diseases among Korean adolescents
Miso Park, Mi Ah Han, Jong Park, Seong Woo Choi
Journal of Asthma.2024; 61(11): 1545. CrossRef
Exploring Disparities for Obesity in Korea Using Hierarchical Age-Period-Cohort Analysis With Cross-Classified Random Effect Models
Chang Kyun Choi, Jung-Ho Yang, Sun-Seog Kweon, Min-Ho Shin
Journal of Korean Medical Science.2024;[Epub] CrossRef
Association of parental depression with adolescent children’s psychological well-being and health behaviors
Sung-In Kim, Sung Min Kim, Sun Jae Park, Jihun Song, Jaewon Lee, Kyae Hyung Kim, Sang Min Park
BMC Public Health.2024;[Epub] CrossRef
A Comparison of Changes in Health Behavior, Obesity, and Mental Health of Korean Adolescents Before and During the COVID-19 Pandemic: Online Cross-Sectional Study
Mi-Sun Lee, Hooyeon Lee
Psychiatry Investigation.2023; 20(11): 1086. CrossRef

Original Articles

Predictive ability of the Chinese visceral adiposity index for incident hypertension in working-aged Koreans: Ju Young Jung, Chang-Mo Oh, Hyun chul Jo, Sung Keun Park; Epidemiol Health. 2024;46:e2024034. Published online February 27, 2024; DOI: https://doi.org/10.4178/epih.e2024034

7,041 View
151 Download
5 Web of Science
5 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
The Chinese visceral adiposity index (CVAI) was developed to assess visceral adipose tissue in the Asian population. This study evaluated the predictive ability of the CVAI for incident hypertension in Korean adults.

METHODS

The study participants included 128,577 Koreans without hypertension. They were grouped in quartiles according to body mass index (BMI), waist circumference (WC), visceral adipose index (VAI), and CVAI values. The Cox proportional hazard assumption was used to evaluate the hazard ratio (HR) and 95% confidence interval (CI) for incident hypertension (adjusted HR [95% CI]) according to quartile level across a follow-up period of 6.9 years. Subgroup analyses were conducted by gender and obesity. The area under the curve was calculated to compare the predictive abilities of all indices (BMI, WC, VAI, and CVAI) for incident hypertension.

RESULTS

The CVAI was proportionally associated with the risk of hypertension in all participants (quartile 1: reference; quartile 2: 1.71 [95% CI, 1.59 to 1.82]; quartile 3: 2.41 [95% CI, 2.25 to 2.58]; and quartile 4: 3.46 [95% CI, 3.23 to 3.71]). Time dependent receiver operating characteristic curve analysis indicated that the CVAI was superior to BMI, WC, and VAI in predicting hypertension at the 2-year, 4-year, 6-year, and 8-year follow-ups. This finding was also observed in the gender and obesity subgroups. The predictive ability of the CVAI was greater in the women and non-obese subgroups than in the men and obese subgroups.

CONCLUSIONS

The CVAI was a stronger predictor of hypertension than BMI, WC, and VAI.

Summary

Korean summary
고혈압은 심혈관 질환의 주요 원인이다. 내장 지방은 비만에서 고혈압의 병태 생리에 중요한 역할을 한다. 최근의 연구는 Chinese visceral adiposity index (CVAI)가 다른 비만 지표 보다 아시아 인에서 심혈관 질환의 고 위험군을 더욱 잘 구분해 낸다는 것을 보고하였다. 우리는 체질량 지수, 허리 둘레, visceral adiposity index, CVAI의 고혈압에 대한 예측력을 비교 하였다. 우리의 연구는 CVAI가 고혈압을 예측하는데 있어 다른 지표 보다 우월하다는 것을 보여주었다.

Key Message
Hypertension is a leading risk factor for cardiovascular disease. It is known that visceral adiposity has an important role in the pathogenesis of hypertension in obesity. Recent studies have demonstrated that Chinese visceral adiposity index (CVAI) is more discriminative the high risk group for cardiovascular disease in Asians than other obesity indices. We compared the predictive ability for the development hypertension among body mass index, waist circumference, visceral adiposity index, and CVAI. Our study showed that CVAI is superior to predict hypertension than other indices.

Citations

Citations to this article as recorded by

Assessment of six surrogate insulin resistance indexes for predicting hypertension risk in rural Chinese adults
Ge Liu, Lu Cao, Hongwei Wen, Mengna Liu, Xinxin He, Mengdi Wang, Yijia Su, Fan Xu, Jingli Kong, Canjie Piao, Aijun Xu, Ming Zhang, Fulan Hu, Dongsheng Hu, Yang Zhao
Hypertension Research.2025; 48(4): 1285. CrossRef
Association of long working hours with visceral adiposity index, anthropometric indices, and weight management behaviors: a study of Korean workers
Seong-Uk Baek, Jin-Ha Yoon
Family Practice.2025;[Epub] CrossRef
Association of traditional and novel obesity indicators with stroke risk: Findings from the Rural Chinese cohort study
Dongdong Zhang, Weifeng Huo, Weiling Chen, Xi Li, Pei Qin, Ming Zhang, Jing Li, Xizhuo Sun, Yu Liu, Dongsheng Hu
Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(9): 2065. CrossRef
Comparison of obesity indicators for predicting cardiovascular risk factors and multimorbidity among the Chinese population based on ROC analysis
Xiang Feng, Jinhua Zhu, Zhaolai Hua, Shenghua Yao, Haiyuan Tong
Scientific Reports.2024;[Epub] CrossRef
Impact of Chinese visceral adiposity index on all-cause mortality risk in community-dwelling older adults: a prospective cohort study
Yuyu Zhang, Mingyue Shi, Zhao Dong, Tingting Li, Yangfan Gong, Wei Ge
Aging Clinical and Experimental Research.2024;[Epub] CrossRef

Association between dietary and behavioral-based oxidative balance score and phenotypic age acceleration: a cross-sectional study of Americans: Dongzhe Wu, Yulin Shen, Chaoyi Qu, Peng Huang, Xue Geng, Jianhong Zhang, Zhijian Rao, Qiangman Wei, Shijie Liu, Jiexiu Zhao; Epidemiol Health. 2024;46:e2024023. Published online January 18, 2024; DOI: https://doi.org/10.4178/epih.e2024023

6,357 View
154 Download
4 Web of Science
5 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
In light of the rise in the global aging population, this study investigated the potential of the oxidative balance score (OBS) as an indicator of phenotypic age acceleration (PhenoAgeAccel) to better understand and potentially slow down aging.

METHODS

Utilizing data from the National Health and Nutrition Examination Survey collected between 2001 and 2010, including 13,142 United States adults (48.7% female and 51.2% male) aged 20 and above, OBS and PhenoAgeAccel were calculated. Weighted generalized linear regression models were employed to explore the associations between OBS and PhenoAgeAccel, including a sex-specific analysis.

RESULTS

The OBS demonstrated significant variability across various demographic and health-related factors. There was a clear negative correlation observed between the higher OBS quartiles and PhenoAgeAccel, which presented sex-specific results: the negative association between OBS and PhenoAgeAccel was more pronounced in male than in female. An analysis using restricted cubic splines revealed no significant non-linear relationships. Interaction effects were noted solely in the context of sex and hyperlipidemia.

CONCLUSIONS

A higher OBS was significantly associated with a slower aging process, as measured by lower PhenoAgeAccel. These findings underscore the importance of OBS as a biomarker in the study of aging and point to sex and hyperlipidemia as variables that may affect this association. Additional research is required to confirm these results and to investigate the biological underpinnings of this relationship.

Summary

Key Message
• The study found a significant negative correlation between the oxidative balance score (OBS) and phenotypic age acceleration (PhenoAgeAccel), with higher OBS associated with slower biological aging. This association was more pronounced in males, and significant in individuals with high cholesterol.
• OBS can serve as an effective biomarker for studying the aging process and its association with lifestyle and dietary factors.

Citations

Citations to this article as recorded by

Association between methyl donor nutrients’ dietary intake with phenotypic aging among US adults: a cross-sectional study from NHANES 2005–2018
Yong Li, Da Peng, Zhenyuan Yu, Jiaqi Deng, Lijuan Zhao, Ruoyan Cao
Scientific Reports.2025;[Epub] CrossRef
Association of oxidative balance score with chronic kidney disease: NHANES 1999-2018
Haibin Wen, Xianhua Li, Jiangming Chen, Yi Li, Nailong Yang, Ning Tan
Frontiers in Endocrinology.2024;[Epub] CrossRef
Association between oxidative balance score and diabetic kidney disease, low estimated glomerular filtration rate and albuminuria in type 2 diabetes mellitus patients: a cross-sectional study
Cong Liu, Jiju Yang, Hongdian Li, Yuanyuan Deng, Pengfei He, Jiao Zhang, Mianzhi Zhang
Frontiers in Endocrinology.2024;[Epub] CrossRef
Dose–response relationship of dietary Omega-3 fatty acids on slowing phenotypic age acceleration: a cross-sectional study
Dongzhe Wu, Yishuai Jia, Yujia Liu, Mingyu Shang
Frontiers in Nutrition.2024;[Epub] CrossRef
Dose-response relationship between leisure-time physical activity patterns and phenotypic age acceleration in American adults: A cross-sectional analysis
Dongzhe Wu, Peng Huang, Xue Geng, Chaoyi Qu, Zhijian Rao, Jianhong Zhang, Yulin Shen, Qiangman Wei, Shijie Liu, Jiexiu Zhao
Journal of Exercise Science & Fitness.2024; 22(4): 445. CrossRef

Trends in the effects of socioeconomic position on physical activity levels and sedentary behavior among Korean adolescents: Hunju Lee, Hyowon Choi, Sang Baek Koh, Hyeon Chang Kim; Epidemiol Health. 2023;45:e2023085. Published online September 8, 2023; DOI: https://doi.org/10.4178/epih.e2023085

8,258 View
176 Download
3 Web of Science
5 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
We examined trends in physical activity and sedentary behavior in Korean adolescents, and their association with socioeconomic position (SEP).

METHODS

We used data from the Korea Youth Risk Behavior Survey, a nationwide study involving students aged 12-19 conducted between 2009 and 2021. SEP was assessed based on economic status, parental education attainment, and urbanization. Physical activity was categorized into vigorous physical activity, moderate physical activity, and muscle training, and sedentary time was also measured. We conducted the log-binomial regression to calculate prevalence ratios (PRs) and prevalence differences.

RESULTS

Our analysis included a total of 593,896 students. We observed an increasing trend in physical activity, but a worsening trend in sedentary behavior. A positive association was found between an adolescent’s physical activity and SEP indicators, except for urbanization. Adolescents with higher economic status engaged in more vigorous physical activity (high: PR, 1.26; 95% confidence interval [CI], 1.25 to 1.28; middle: PR, 1.03; 95% CI, 1.02 to 1.04). Similar associations were observed for father’s education (tertiary or above: PR, 1.11; 95% CI, 1.09 to 1.13; upper secondary: PR, 1.05; 95% CI, 1.03 to 1.07) and mother’s education (tertiary or above: PR, 1.17; 95% CI, 1.15 to 1.20; upper secondary: PR, 1.06; 95% CI, 1.04 to 1.08). Adolescents with higher economic status also showed a higher compliance rate with the guideline restricting sedentary time to 2 hours per day (high: PR, 1.28; 95% CI, 1.25 to 1.30; middle: PR, 1.03; 95% CI, 1.01 to 1.05).

CONCLUSIONS

Adolescents with higher SEP exhibited more physical activity and less sedentary time than those with lower SEP.

Summary

Korean summary
본 연구는 2009년부터 2021년까지 청소년의 사회경제적 지위가 신체활동과 좌식생활습관에 미치는 영향을 분석하였다. 청소년의 경제적 상태, 아버지와 어머니의 교육수준이 높을수록 청소년의 신체활동이 증가하고 좌식생활이 감소하였다. 그러나 청소년이 사는 지역의 도시화 정도는 영향을 미치지 않았다.

Key Message
This article analyzes the effects of an adolescent's socio-economic position on their physical activity and sedentary behavior from 2009 to 2021. The higher the adolescent's economic status, father's education, or mother's education, the more they engaged in physical activity and the less time they spent in sedentary behaviors. However, the level of urbanization in the area where the adolescent resided had no effect.

Citations

Citations to this article as recorded by

Global trends in importance of 24-hour movement behaviors to pediatric health: implications for South Korea
Eun-Young Lee, Reyana Jayawardena, Seiyeong Park, Justin Y Jeon, Yeon-Soo Kim, Mark S. Tremblay
Clinical and Experimental Pediatrics.2025; 68(1): 16. CrossRef
Socioeconomic disparities in depression risk: Limitations of the moderate effect of physical activity changes in Korea
Su Kyoung Lee, Yong Jin Kwon, Zulkarnain Jaafar
PLOS ONE.2025; 20(2): e0314930. CrossRef
Using structural equation modeling to explore the influences of physical activity, mental health, well-being, and loneliness on Douyin usage at bedtime
Hongcheng Luo, Xing Zhang, Songpeng Su, Mingyang Zhang, Mingyue Yin, Siyuan Feng, Rui Peng, Hansen Li
Frontiers in Public Health.2024;[Epub] CrossRef
The Association between Social Isolation and Physical Activity among Korean Adolescents
Sarang Jang, Na-Young Park
Children.2024; 11(8): 1003. CrossRef
Analysis of Nutrition Knowledge After One Year of Intervention in a National Extracurricular Athletics Program: A Cross-Sectional Study with Pair-Matched Controls of Polish Adolescents
Dominika Skolmowska, Dominika Głąbska, Dominika Guzek, Jakub Grzegorz Adamczyk, Hanna Nałęcz, Blanka Mellová, Katarzyna Żywczyk, Krystyna Gutkowska
Nutrients.2024; 17(1): 64. CrossRef

Adherence to the World Cancer Research Fund/American Institute for Cancer Research and Korean Cancer Prevention Guidelines and cancer risk: a prospective cohort study from the Health Examinees-Gem study: Jeeyoo Lee, Aesun Shin, Woo-Kyoung Shin, Ji-Yeob Choi, Daehee Kang, Jong-Koo Lee; Epidemiol Health. 2023;45:e2023070. Published online August 1, 2023; DOI: https://doi.org/10.4178/epih.e2023070

9,270 View
222 Download
5 Web of Science
5 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
The purpose of this study was to explore the association between adherence to 2 cancer prevention recommendations and cancer risk.

METHODS

In total, 104,386 individuals aged 40-69 years old who were recruited between 2004 and 2013 in the Health Examinees-Gem study were included. Adherence scores were constructed based on 8 items from the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations, including body weight, physical activity, diet, alcohol consumption and breastfeeding, and on 6 items from the Korean cancer prevention guidelines (smoking status, eating vegetables and fruits, salty foods, alcohol intake, physical activity, and body weight). A Cox proportional hazards model was used to estimate the associations between adherence scores and the risk of total and 5 major cancers.

RESULTS

The multivariable hazard ratio (HR) for total cancer with the high adherence score versus the lowest score (4.25-7.00 vs. 0.00-3.25) for the WCRF/AICR guidelines was 0.91 (95% confidence interval [CI], 0.82 to 1.00) in men. A reduced breast cancer risk was observed among women with the highest score. Men within the highest category of the Korean cancer prevention guideline score (3.25-6.00) had an HR of 0.80 (95% CI, 0.73 to 0.88) for developing total cancer compared to men within the lowest score (0.00-2.50). The higher adherence group among men showed lower risks of developing stomach, colorectal, and lung cancers.

CONCLUSIONS

Adhering to guidelines for cancer prevention can help to reduce the risk of developing cancer in Korean men. The association might differ by cancer type and gender.

Summary

Korean summary
- 암예방 가이드라인 준수가 실제로 암 발생을 예방하는지에 대한 해외 연구들이 다수 있으나 한국을 포함한 아시아 국가에서 수행된 연구는 없다. - 국제암연구재단 암예방수칙과 한국 암예방수칙을 준수하는 한국인 남성에서 암 발생 감소가 관찰되었다. 이러한 관련성은 암종에 따라 다르게 나타났다.

Key Message
- The adherence to the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) guidelines on cancer prevention has been addressed in several studies in Western countries. -Among the Korean population, adherence to WCRF/AICR cancer prevention guidelines as well as the Korean cancer prevention guidelines helps prevent cancer in men. Association varies by gender and type of cancer.

Citations

Citations to this article as recorded by

Heterogeneous Clustering of Multiomics Data for Breast Cancer Subgroup Classification and Detection
Joseph Pateras, Musaddiq Lodi, Pratip Rana, Preetam Ghosh
International Journal of Molecular Sciences.2025; 26(4): 1707. CrossRef
Compliance with the WCRF/AICR Recommendations in Qualitative Adaptation and the Occurrence of Breast Cancer: A Case-Control Study
Beata Stasiewicz, Lidia Wadolowska, Maciej Biernacki, Malgorzata Anna Slowinska, Ewa Stachowska
Cancers.2024; 16(2): 468. CrossRef
Transforming public health and economic outcomes by reducing risky behaviors: the potential for South Korea
Joan E. Madia, Ji Yoon Baek, Aesun Shin
Discover Social Science and Health.2024;[Epub] CrossRef
Alcoholic beverage consumption and female breast cancer risk: A systematic review and meta‐analysis of prospective cohort studies
Ivneet Sohi, Jürgen Rehm, Marian Saab, Lavanya Virmani, Ari Franklin, Gonzalo Sánchez, Mihojana Jhumi, Ahmed Irshad, Hiya Shah, Daniela Correia, Pietro Ferrari, Carina Ferreira‐Borges, Beatrice Lauby‐Secretan, Gauden Galea, Susan Gapstur, Maria Neufeld, H
Alcohol, Clinical and Experimental Research.2024; 48(12): 2222. CrossRef
Adherence to the Cancer Prevention Recommendations from World Cancer Research Fund/American Institute for Cancer Research After Cancer Diagnosis on Mortality in South Korea
Donghyun Won, Jeeyoo Lee, Sooyoung Cho, Ji Yoon Baek, Daehee Kang, Aesun Shin
Nutrients.2024; 16(23): 4049. CrossRef

First
Prev
Page of 9
Next
Last

Most cited articles