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Korean J Parasitol. 2009 Oct;47(Suppl):S51-S58.
Published online 2009 October 26.  doi: 10.3347/kjp.2009.47.S.S51.
Copyright © 2009 by The Korean Society for Parasitology
Genetic Characteristics of Polymorphic Antigenic Markers among Korean Isolates of Plasmodium vivax
Seung-Young Hwang,1 So-Hee Kim,2 and Weon-Gyu Kho1,2,3
1Department of Parasitology, Inje University College of Medicine, Busan 614-735, Korea.
2Department of Malariology, Paik Institute for Clinical Research, Inje University, Busan 614-735, Korea.
3Mitochondrial Research Group, Frontier Inje Research for Science and Technology, Inje University, Busan 614-735, Korea.

Corresponding author (Email: wgkho@inje.ac.kr )
Received August 06, 2009; Revised September 28, 2009; Accepted September 28, 2009.

Abstract

Plasmodium vivax, a protozoan malaria parasite of humans, represents a major public health concern in the Republic of Korea (= South Korea). However, little is known about the genetic properties and population structures of the P. vivax isolates circulating in South Korea. This article reviews known polymorphic genetic markers in South Korean isolates of P. vivax and briefly summarizes the current issues surrounding the gene and population structures of this parasite. The critical genetic characteristics of major antigens of the parasite, such as circumsporozoite protein (CSP), merozoite surface protein 1 (MSP-1) and MSP-3, Duffy binding protein (DBP), apical membrane antigen 1 (AMA-1), and GAM-1, are also discussed.

Keywords: Plasmodium vivax, antigenic protein, genetic polymorphism, South Korean strain.
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