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Korean J Parasitol. 2009 Oct;47(Suppl):S125-S131.
Published online 2009 October 26.  doi: 10.3347/kjp.2009.47.S.S125.
Copyright © 2009 by The Korean Society for Parasitology
Eosinophil-Mediated Tissue Inflammatory Responses in Helminth Infection
Myeong Heon Shin,1,2 Young Ah Lee,1,2 and Duk-Young Min3
1Department of Environmental Medical Biology, and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea.
2Brain Korea 21 for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea.
3Department of Microbiology and Immunology, Eulji University College of Medicine, Daejeon 301-746, Korea.

Corresponding author (Email: myeong@yuhs.ac )
Received September 23, 2009; Revised October 05, 2009; Accepted October 05, 2009.

Abstract

Eosinophilic leukocytes function in host protection against parasitic worms. In turn, helminthic parasites harbor specific molecules to evade or paralyze eosinophil-associated host immune responses; these molecules facilitate the migration and survival of parasitic helminths in vivo. This competition between eosinophil and worm leads to stable equilibria between them. An understanding of such dynamic host-eosinophil interactions will help us to uncover mechanisms of cross talk between host and parasite in helminth infection. In this review, we examine recent findings regarding the innate immune responses of eosinophils to helminthic parasites, and discuss the implications of these findings in terms of eosinophil-mediated tissue inflammation in helminth infection.

Keywords: Eosinophils, Helminth infection, Tissue inflammation, Host-parasite interaction.
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